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Multipotent cell lineages in early mouse development depend on SOX2 function.
The data suggest that maternal components could be involved in establishing early cell fate decisions and that a combinatorial code, requiring SOX2 and OCT4, specifies the first three lineages present at implantation.
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
Male development of chromosomally female mice transgenic for Sry
It is shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
Expression of Sry, the mouse sex determining gene.
This work uses RNase protection to map the extent of the less abundant Sry transcript in the developing gonad and demonstrates that it is a linear mRNA derived from a single exon, which defines the critical period during which Sry must act to initiate Sertoli cell differentiation.
Sox2 is required for sensory organ development in the mammalian inner ear
It is reported here that inner ears of Lcc/Lcc mice fail to establish a prosensory domain and neither hair cells nor supporting cells differentiate, resulting in a severe inner ear malformation, whereas the sensory epithelium of Ysb/Ysb mice shows abnormal development with disorganized and fewer hair cells.
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent
Fgf9 and Wnt4 Act as Antagonistic Signals to Regulate Mammalian Sex Determination
It is shown through gain- and loss-of-function experiments that fibroblast growth factor 9 (FGF9) and WNT4 act as opposing signals to regulate sex determination, and the fate of the gonad is controlled by antagonism between Fgf9 and Wnt4.
Expression of a candidate sex-determining gene during mouse testis differentiation
The observations strongly support a primary role for Sry in mouse sex determination, and further the involvement of this gene, Sry, in testis development, which is studied in detail.
Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation
The results show that maintenance of the ovarian phenotype is an active process throughout life and might have important medical implications for the understanding and treatment of some disorders of sexual development in children and premature menopause in women.