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Characterization of a snake venom neurotoxin which blocks nicotinic transmission in the avian ciliary ganglion
Bungarus multicinctus venom was fractionated by ion exchange chromatography and the various fractions were assayed for their ability to block synaptic transmission through the chick ciliary ganglion.Expand
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Selective modulation of NMDA responses by reduction and oxidation
Electrophysiological responses to the glutamate analog N-methyl-D-aspartate (NMDA) measured in three different central neuronal preparations are subject to a novel modulatory mechanism: they areExpand
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Ultrastructural distribution of 125I-toxin F binding sites on chick ciliary neurons: synaptic localization of a toxin that blocks ganglionic nicotinic receptors
Although alpha-bungarotoxin (BGT), a common probe for nicotinic ACh receptors from vertebrate skeletal muscle, binds tightly to many autonomic ganglia, it fails to block nicotinic transmission inExpand
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Localization of α-bungarotoxin binding sites in the ciliary ganglion of the embryonic chick: An autoradiographic study at the light and electron microscopic level
Binding sites for [125I]alpha-bungarotoxin were localized in the chick ciliary ganglion by light and electron microscopic autoradiography. Groups of four ganglia were incubated for 4 h with 20 nMExpand
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Amino acid sequence of toxin F, a snake venom toxin that blocks neuronal nicotinic receptors
The amino acid sequence was determined for toxin F, a component of Bungarus multicinctus venom that blocks nicotinic transmission in the chick ciliary ganglion and the rat superior cervical ganglion.Expand
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Multistep expression and assembly of neuronal nicotinic receptors is both host-cell- and receptor-subtype-dependent.
We tested the hypothesis that the folding, assembly and insertion of neuronal nicotinic receptors are critically dependent on the host cell line. We used recombinant adenoviruses encoding either theExpand
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Assessing the limitations to terpenoid indole alkaloid biosynthesis in Catharanthus roseus hairy root cultures through gene expression profiling and precursor feeding
The production of pharmaceutically important terpenoid indole alkaloids (TIAs) from Catharanthus roseus is partly regulated at the transcriptional level. In this study, limitations in TIAExpand
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Cell‐specific effects on surface α7 nicotinic receptor expression revealed by over‐expression and knockdown of rat RIC3 protein
We tested whether surface α7 nicotinic acetylcholine receptor expression is dependent on an endogenous chaperone named Resistance to Inhibitors of Cholinesterase 3 (RIC3) by comparing RIC3 protein inExpand
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Characterization of neuronal nicotinic receptors by snake venom neurotoxins
Abstract Neuronal nicotinic ACh receptors differ pharmacologically from nicotinic receptors on skeletal muscle. The use of certain snake venom neurotoxins has now led to a more complete determinationExpand
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