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Effects of lovastatin (mevinolin) on sterol levels and on activity of azoles in Saccharomyces cerevisiae.
The hypocholesterolemic drug lovastatin (mevinolin) was found to be very effective in lowering the sterol levels of the wild-type yeast Saccharomyces cerevisiae. Lovastatin dramatically decreased the… Expand
Cloning, sequencing, and disruption of the gene encoding sterol C-14 reductase in Saccharomyces cerevisiae.
A sterol C-14 reductase (erg24-1) mutant of Saccharomyces cerevisiae was selected in a fen1, fen2, suppressor background on the basis of nystatin resistance and ignosterol (ergosta-8,14-dienol)… Expand
Physiological effects of fenpropimorph on wild-type Saccharomyces cerevisiae and fenpropimorph-resistant mutants.
Fenpropimorph-resistant mutants of Saccharomyces cerevisiae were isolated by a gradient selection procedure. The mutants were cross-resistant to other morpholines (fenpropidin, dodemorph, tridemorph)… Expand
Characteristics of sterol uptake in Saccharomyces cerevisiae.
- R. Lorenz, R. J. Rodriguez, T. Lewis, L. Parks
- Biology, Medicine
- Journal of bacteriology
- 1 September 1986
A Saccharomyces cerevisiae sterol auxotroph, FY3 (alpha hem1 erg7 ura), was used to probe the characteristics of sterol uptake in S. cerevisiae. The steady-state cellular concentration of free sterol… Expand
Structural discrimination in the sparking function of sterols in the yeast Saccharomyces cerevisiae.
A Saccharomyces cerevisiae sterol auxotroph, SPK14 (a hem1 erg6 erg7 ura), was constructed to test the ability of selected C-5,6 unsaturated sterols at growth-limiting concentrations to spark growth… Expand
Involvement of heme components in sterol metabolism ofSaccharomyces cerevisiae
There is an intimate association between sterol biosynthesis in yeast and aerobicity. Besides the requirement for molecular oxygen for the epoxidation of squalene, cytochrome hemoproteins are… Expand
Regulation of ergosterol biosynthesis and sterol uptake in a sterol-auxotrophic yeast.
Inhibition of sterol uptake in Saccharomyces cerevisiae sterol auxotroph FY3 (alpha hem1 erg7 ura) by delta-aminolevulinic acid (ALA) is dependent on the ability of the organism to synthesize heme… Expand
Fenpropimorph affects uptake of uracil and cytosine in Saccharomyces cerevisiae.
Fenpropimorph was shown to inhibit the accumulation of the pyrimidine bases uracil and cytosine from the growth media in Saccharomyces cerevisiae. Uracil prototrophs of S. cerevisiae were more… Expand
Functions for Sterols in Yeast Membranes
Most of the clinically useful antifungal agents either interact directly with the sterols in the fungal membrane or interfere with the synthesis of fungal sterols. The characteristics of these agents… Expand