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Clustal W and Clustal X version 2.0
SUMMARY The Clustal W and Clustal X multiple sequence alignment programs have been completely rewritten in C++. This will facilitate the further development of the alignment algorithms in the futureExpand
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
A new program called Clustal Omega is described, which can align virtually any number of protein sequences quickly and that delivers accurate alignments, and which outperforms other packages in terms of execution time and quality. Expand
Multiple sequence alignment with the Clustal series of programs
The Clustal series of programs are widely used in molecular biology for the multiple alignment of both nucleic acid and protein sequences and for preparing phylogenetic trees. The popularity of theExpand
InterProScan 5: genome-scale protein function classification
A new Java-based architecture for the widely used protein function prediction software package InterProScan is described, resulting in a flexible and stable system that is able to use both multiprocessor machines and/or conventional clusters to achieve scalable distributed data analysis. Expand
UniProt: the Universal Protein knowledgebase
The Swiss-Prot, TrEMBL and PIR protein database activities have united to form the Universal Protein Knowledgebase (UniProt), which is to provide a comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and query interfaces. Expand
InterProScan: protein domains identifier
InterProScan is a tool that combines different protein signature recognition methods from the InterPro consortium member databases into one resource and can be analysed for protein as well as DNA sequences. Expand
The Universal Protein Resource (UniProt)
During 2004, tens of thousands of Knowledgebase records got manually annotated or updated; the UniProt keyword list got augmented by additional keywords; the documentation of the keywords and are continuously overhauling and standardizing the annotation of post-translational modifications. Expand
InterPro: the integrative protein signature database
The InterPro database integrates together predictive models or ‘signatures’ representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY and TIGRFAMs. Expand
A new bioinformatics analysis tools framework at EMBL–EBI
A new framework aimed at both novice as well as expert users that exposes novel methods of obtaining annotations and visualizing sequence analysis results through one uniform and consistent interface is presented. Expand
The Universal Protein Resource (UniProt): an expanding universe of protein information
The Universal Protein Resource (UniProt) provides a central resource on protein sequences and functional annotation with three database components, each addressing a key need in proteinExpand