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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- B. A. Neuschwander-Tetri, R. Loomba, A. Sanyal, J. Lavine, for the Nash Clinical Research Network
- The Lancet
- 14 March 2015
BACKGROUND The bile acid derivative 6-ethylchenodeoxycholic acid (obeticholic acid) is a potent activator of the farnesoid X nuclear receptor that reduces liver fat and fibrosis in animal models of… Expand
Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies.
- S. Singh, A. Allen, Z. Wang, L. Prokop, M. Murad, R. Loomba
- Clinical gastroenterology and hepatology : the…
- 1 April 2015
BACKGROUND & AIMS Little is known about differences in rates of fibrosis progression between patients with nonalcoholic fatty liver (NAFL) vs nonalcoholic steatohepatitis (NASH). We conducted a… Expand
The global NAFLD epidemic
NAFLD is a clinical syndrome characterized by predominant macrovesicular steatosis of the liver. The clinical and histological phenotypes of NAFLD extend from a nonalcoholic fatty liver to NASH.… Expand
Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta‐analysis
Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease (NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically evaluated. We… Expand
Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis
Previous studies have shown familial aggregation of insulin resistance and nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to examine whether family history of diabetes mellitus (DM) is… Expand
Magnetic Resonance Elastography Predicts Advanced Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Study
Retrospective studies have shown that two‐dimensional magnetic resonance elastography (2D‐MRE), a novel MR method for assessment of liver stiffness, correlates with advanced fibrosis in patients with… Expand
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
BACKGROUND & AIMS Little data are available from genome-wide association studies (GWASs) of liver histology in patients with nonalcoholic fatty liver disease (NAFLD). We conducted a pilot GWAS in… Expand
The gut–liver axis and the intersection with the microbiome
- Anupriya Tripathi, Justine W. Debelius, +4 authors R. Knight
- Nature Reviews Gastroenterology & Hepatology
- 10 May 2018
In the past decade, an exciting realization has been that diverse liver diseases — ranging from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular carcinoma —… Expand
Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis.
PURPOSE To evaluate the diagnostic performance of magnetic resonance (MR) imaging-estimated proton density fat fraction (PDFF) for assessing hepatic steatosis in nonalcoholic fatty liver disease… Expand
Correlation between liver histology and novel magnetic resonance imaging in adult patients with non‐alcoholic fatty liver disease – MRI accurately quantifies hepatic steatosis in NAFLD
Conventional magnetic resonance imaging (MRI) techniques that measure hepatic steatosis are limited by T1 bias, T2* decay and multi‐frequency signal‐interference effects of protons in fat. Newer MR… Expand