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Initiation of base excision repair: glycosylase mechanisms and structures.
The base excision repair pathway is an organism's primary defense against mutations induced by oxidative, alkylating, and other DNA-damaging agents. This pathway is initiated by DNA glycosylases that… Expand
MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily
- Y. Guan, R. C. Manuel, +5 authors J. Tainer
- Chemistry, Medicine
- Nature Structural Biology
- 1 December 1998
The DNA glycosylase MutY, which is a member of the Helix-hairpin-Helix (HhH) DNA glycosylase superfamily, excises adenine from mispairs with 8-oxoguanine and guanine. High-resolution crystal… Expand
Structural similarities between MutT and the C-terminal domain of MutY.
One of the functions of MutY from Escherchia coli is removal of adenine mispaired with 7,8-dihydro-8-oxoguanine (8-oxoG), a common lesion in oxidatively damaged DNA. MutY is composed of two domains:… Expand
1,N 2-Deoxyguanosine Adducts of Acrolein, Crotonaldehyde, and trans-4-Hydroxynonenal Cross-link to Peptides via Schiff Base Linkage*
DNA-protein cross-links (DPCs) are formed upon exposure to a variety of chemical and physical agents and pose a threat to genomic integrity. In particular, acrolein and related aldehydes produce… Expand
Isolation and characterization of cDNA clones for rat liver 10-formyltetrahydrofolate dehydrogenase.
We have isolated and characterized cDNA clones encoding rat liver cytosol 10-formyltetrahydrofolate dehydrogenase (EC 126.96.36.199). An open reading frame of 2706 base pairs encodes for 902 amino acids of… Expand
Bleomycin-specific fragmentation of double-stranded DNA.
Brief exposure of covalently closed circular duplex PM2 DNA to low concentrations of the clinical bleomycin mixture (Blenoxane) resulted in specific fragmentation of the genome that does not depend… Expand
Unified catalytic mechanism for DNA glycosylases.
Studies on the Catalytic Mechanism of Five DNA Glycosylases
- B. Sun, K. Latham, M. L. Dodson, R. Lloyd
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 18 August 1995
DNA glycosylases catalyze scission of the N-glycosylic bond linking a damaged base to the DNA sugar phosphate backbone. Some of these enzymes carry out a concomitant abasic (apyrimidinic/apurinic… Expand
Processivity of uracil DNA glycosylase.
The purpose of this study was to determine the mechanism by which uracil DNA glycosylase locates uracil residues within double-stranded DNA. Using reaction conditions that contained low salt… Expand
AP lyases and dRPases: commonality of mechanism.
Enzymes that release 5'-deoxyribose-5-phosphate (dRP) residues from preincised apurinic/apyrimidinic (AP) DNA have been collectively termed DNA deoxyribophosphodiesterases (dRPases), but they fall… Expand