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Synthesis of long prebiotic oligomers on mineral surfaces
MOST theories of the origin of biological organization assume that polymers with lengths in the range of 30–60 monomers are needed to make a genetic system viable1. But it has not proved possible to… Expand
LOVTRAP, An Optogenetic System for Photo-induced Protein Dissociation
LOVTRAP is an optogenetic approach for reversible light-induced protein dissociation using protein A fragments that bind to the LOV domain only in the dark, with tunable kinetics and a >150-fold… Expand
Ca2+/Calmodulin Directly Interacts with the Pleckstrin Homology Domain of AKT1*
AKT kinase, also known as protein kinase B, is a key regulator of cell growth, proliferation, and metabolism. The activation of the AKT signaling pathway is one of the most frequent molecular… Expand
Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
Although great success has been obtained in the clinic, the current immune checkpoint inhibitors still face two challenging problems: low response rate and immune-related adverse effects (irAEs).… Expand
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
Pharmacophore/receptor models for three recombinant GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) have been established via an SAR ligand-mapping approach. This… Expand
Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies
CAR T-cell antitumor therapy fails when the tumor loses expression of the chosen epitope. Receptors that mimic antibodies and that recognize two epitopes may reduce the chances for tumor cells to… Expand
Molecular analysis of human cardiac myosin-cross-reactive B- and T-cell epitopes of the group A streptococcal M5 protein.
- M. Cunningham, S. Antone, M. Smart, R. Liu, S. Kosanke
- Biology, Medicine
- Infection and immunity
- 1 September 1997
The group A streptococcal M protein is an important virulence determinant eliciting protective and autoimmune responses against the streptococcus and cardiac myosin, respectively. In this report, the… Expand
The smart targeting of nanoparticles.
- Adam D. Friedman, Sarah E. Claypool, R. Liu
- Chemistry, Medicine
- Current pharmaceutical design
- 30 September 2013
One major challenge in nanomedicine is the selective delivery of nanoparticles to diseased tissues. Nanoparticle delivery systems require targeting for specific delivery to pathogenic sites when… Expand
Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer.
Multivalency is the increase in avidity resulting from the simultaneous interaction of multiple ligands with multiple receptors. This phenomenon, seen in antibody-antigen and virus-cell membrane… Expand
Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels.
The novel antiepileptic drug, (R)-N-benzyl 2-acetamido-3-methoxypropionamide ((R)-lacosamide, Vimpat(®) ((R)-1)), was recently approved in the US and Europe for adjuvant treatment of partial-onset… Expand