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Rapid movement of axonal neurofilaments interrupted by prolonged pauses
The direct observation of the axonal transport of neurofilament protein tagged with green fluorescent protein in cultured nerve cells reveals rapid, intermittent and highly asynchronous movement of fluorescent neurofilaments. Expand
Neurofilaments Are Transported Rapidly But Intermittently in Axons: Implications for Slow Axonal Transport
Time lapse imaging revealed that individual GFP–NFH-labeled neurofilaments undergo vigorous vectorial transport in the axon in both anterograde and retrograde directions but with a strong anterOGrade bias, establishing that the slow axonal transport machinery conveys neurofilms. Expand
Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins.
The C-terminus of MACF contains at least two microtubule-binding regions, a GAR domain and a domain containing glycine-serine-arginine (GSR) repeats, which shows that the GSR-containing domain of plectin, but not desmoplakin, can bind to MTs in vivo. Expand
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy
A missense mutation in the gene encoding 27-kDa small heat-shock protein B1 (HSPB1, also called HSP27) that segregates in the family with CMT2F is reported and four additional missense mutations are identified. Expand
Plakins: a family of versatile cytolinker proteins.
The members of the plakin family and their interaction partners are described, and examples of the cellular defects that result from their dysfunction are given. Expand
Astroglia in CNS injury
Both in vivo and in vitro studies on neuron‐glia interactions in different brain regions suggest that glia express region‐specific properties, including ion channels, neurotransmitter uptake and receptor systems, and cell surface adhesion systems. Expand
Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments
  • G. Ching, R. Liem
  • Biology, Medicine
  • The Journal of cell biology
  • 2 September 1993
The results suggest that the tail domains of NF-L and NF-M are dispensable for normal coassembly of each of these proteins with other type IV intermediate filament proteins to form filaments. Expand
Microtubule Actin Cross-Linking Factor (Macf)
It is demonstrated that the NH2-terminal actin-binding domain of mouse actin cross-linking family 7 is functional both in vivo and in vitro, and it is found that the COOH- terminus of mACF7 interacts with and stabilizes microtubules. Expand
Plakins in development and disease.
Two other mammalian plakins, Bullous pemphigoid antigen 1 (BPAG1) and microtubule actin cross-linking factor 1 (MACF1), that are expressed in multiple isoforms in different tissues are described and their relationship to the spectrin superfamily of proteins is described. Expand
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.
A new role of MACF1 is suggested in the Wnt signaling pathway, a DNA-binding transcription factor that is a direct target of Wnt/beta-catenin signaling and required for mesoderm formation. Expand