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A Model of the Lower Limb for Analysis of Human Movement
- Edith M. Arnold, S. Ward, R. Lieber, S. Delp
- Engineering, Medicine
- Annals of Biomedical Engineering
- 1 February 2010
A new model of the lower limb based on data that quantifies the muscle architecture of 21 cadavers is described, which includes geometric representations of the bones, kinematic descriptions of the joints, and Hill-type models of 44 muscle–tendon compartments. Expand
Are Current Measurements of Lower Extremity Muscle Architecture Accurate?
- S. Ward, C. Eng, Laura H. Smallwood, R. Lieber
- Clinical orthopaedics and related research
- 1 April 2009
This work disassembled 27 muscles from 21 human lower extremities to characterize muscle fiber length and physiologic cross-sectional area, which define the excursion and force-generating capacities of a muscle. Expand
Skeletal Muscle Structure, Function, and Plasticity: The Physiological Basis of Rehabilitation
- R. Lieber
- 15 July 2002
Education Objectives and Implications for Physical Therapy: Muscle Development, Muscle Properties after Regeneration, and Response to Exercise-Induced Injury. Expand
Functional and clinical significance of skeletal muscle architecture
The basic architectural properties of human upper and lower extremity muscles are described and the ability of muscles to change their architecture in response to immobilization, eccentric exercise, and surgical tendon transfer is reviewed. Expand
Relationship between muscle fiber types and sizes and muscle architectural properties in the mouse hindlimb
This study uses discriminant analysis and mathematical modeling to identify the structurally and functionally significant properties of fiber length, muscle length, and pennation angle, and found that there does seem to be a synergistic relation between the two property classes and force production. Expand
Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle
The functional importance of nebulin in skeletal muscle function was revealed by isometric contractility assays, which demonstrated a dramatic reduction in force production in nebulin-deficient skeletal muscle. Expand
Eccentric exercise-induced injuries to contractile and cytoskeletal muscle fibre components.
It is concluded that muscle injury after eccentric exercise is differently severe in muscles with different architecture, is fibre type-specific, primarily because of fibre strain in the acute phase, and is exacerbated by inflammation after the initial injury. Expand
Sarcomere length operating range of vertebrate muscles during movement.
The analysis suggests that many muscles operate over a narrow range of sarcomere lengths, covering 94+/-13 % of optimal Sarcomere length. Expand
Muscle damage is not a function of muscle force but active muscle strain.
It is concluded that it is not high force per se that causes muscle damage after eccentric contraction but the magnitude of the active strain (i.e., strain during active lengthening), supported by morphometric analysis showing equivalent area fractions of damaged muscle fibers that were observed throughout the muscle cross section. Expand
Structure and function of the skeletal muscle extracellular matrix
The structure, composition, and mechanical properties of skeletal muscle ECM are reviewed; the cells that contribute to the maintenance of the ECMAreas for future study are proposed; and overview changes that occur with pathology are described. Expand