• Publications
  • Influence
Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome.
The DNA context of nucleotides that a protein recognizes can influence the strength of the protein-DNA interaction. Moreover, in prokaryotes, understanding the quantitative differences in bindingExpand
  • 154
  • 9
  • Open Access
Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast
We have established an in vitro assay for assembly of the cortical actin cytoskeleton of budding yeast cells. After permeabilization of yeast by a novel procedure designed to maintain the spatialExpand
  • 152
  • 8
  • Open Access
Long-term effects of eliminating illegal logging on the world forest industries, trade, and inventory
We assessed the impact on the world forest sector of a progressive elimination of illegal logging. The analysis compared predictions from 2007 to 2020, with and without a gradual reduction ofExpand
  • 64
  • 8
  • Open Access
Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1.
  • R. Li, M. Botchan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 19 July 1994
The papillomavirus E2 transcription factor is directly involved in viral DNA replication. Previous studies have shown that E2 interacts with both the viral E1 helicase and cellular replicationExpand
  • 114
  • 6
Forecasts of forest conditions in regions of the United States under future scenarios: a technical document supporting the Forest Service 2012 RPA Assessment.
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  • 30
  • 6
  • Open Access
Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy.
For nearly a century, cancer has been blamed on somatic mutation. But it is still unclear whether this mutation is aneuploidy, an abnormal balance of chromosomes, or gene mutation. Despite enormousExpand
  • 257
  • 5
  • Open Access
The Chromosomal Basis of Cancer
Conventional genetic theories have failed to explain why cancer (1) is not heritable and thus extremely rare in newborns, (2) is caused by non-mutagenic carcinogens, (3) develops only years toExpand
  • 172
  • 4
  • Open Access
Cancer drug resistance: the central role of the karyotype.
Current genetic and epigenetic theories of cancer-specific drug resistance do not adequately explain: (i) the karyotypic changes that coincide with resistance, (ii) the high rates at which cancerExpand
  • 100
  • 4
  • Open Access
Multistep Carcinogenesis: A Chain Reaction of Aneuploidizations
Carcinogenesis is a multistep process in which new, parasitic and polymorphic cancer cells evolve from a single, normal diploid cell. This normal cell is converted to a prospective cancer cell, aliasExpand
  • 186
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  • Open Access
Aneuploidy and cancer: from correlation to causation.
Conventional genetic theories have failed to explain why cancer (1) is not found in newborns and thus not heritable; (2) develops only years to decades after 'initiation' by carcinogens; (3) isExpand
  • 90
  • 3
  • Open Access