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Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.
Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disease caused by expansion of a CAG repeat encoding a polyglutamine tract in ATXN7, a component of the SAGA histone acetyltransferaseExpand
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The Emerging Chondrocyte Channelome
Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytesExpand
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Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle.
Insulin action in skeletal muscle is enhanced by regular exercise. Whether insulin signaling in human skeletal muscle is affected by habitual exercise is not well understood. PhosphatidylinositolExpand
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The Role of the Membrane Potential in Chondrocyte Volume Regulation
Many cell types have significant negative resting membrane potentials (RMPs) resulting from the activity of potassium‐selective and chloride‐selective ion channels. In excitable cells, such asExpand
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Cell Volume Regulation in Chondrocytes
Chondrocytes are the cells within cartilage which produce and maintain the extracellular matrix. Volume regulation in these cells is vital to their function and occurs in several differentExpand
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Characterization of a stretch-activated potassium channel in chondrocytes
Chondrocytes possess the capacity to transduce load‐induced mechanical stimuli into electrochemical signals. The aim of this study was to functionally characterize an ion channel activated inExpand
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Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes
Chondrocytes exist within cartilage and serve to maintain the extracellular matrix. It has been postulated that osteoarthritic (OA) chondrocytes lose the ability to regulate their volume, affectingExpand
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TRPV4 and KCa ion channels functionally couple as osmosensors in the paraventricular nucleus
Transient receptor potential vanilloid type 4 (TRPV4) and calcium‐activated potassium channels (KCa) mediate osmosensing in many tissues. Both TRPV4 and KCa channels are found in the paraventricularExpand
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Significant changes in VLDL-Triacylglycerol and glucose tolerance in obese subjects following ten days of training
Abstract We characterized the effect of ten days of training on lipid metabolism in 6 [age 37.2 (2.3) years] sedentary, obese [BMI 34.4 (3.0) kg · m−2] males with normal glucose tolerance. An oralExpand
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Ion Channels and Osteoarthritic Pain: Potential for Novel Analgesics
Osteoarthritis (OA) is a debilitating chronic condition widely prevalent in ageing populations. Because the pathology of the disease includes cartilage erosion and joint remodelling, OA patientsExpand
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