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The carbonic anhydrase inhibitor, 6-amino-2-benzothiazolesulfonamide, formulated as a 3% suspension in a gel vehicle was instilled in one eye of 21 human subjects in a single dose study to determine… Expand
Two metabolites of anticonvulsant U-54494A: their anticonvulsant activity and interaction with sodium channel
U-54494A, 3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzamide, has been shown to be a potent and long-acting anticonvulsant without analgesic or sedative effects on intact animals. The… Expand
Selective endothelin A receptor ligands. 1. Discovery and structure-activity of 2,4-disubstituted benzoic acid derivatives
Summary This paper describes the discovery of a new non-peptide endothelin A (ETA) selective ligand, 2,4-dibenzyloxybenzoic acid 3, which inhibits the binding of [125I]ET-1 to ETA receptors with an… Expand
Synthesis of pyridine fused polycyclic amines using sequential ring-closing metathesis and radical cyclisation reactions
The syntheses of novel pyridine fused polycyclic bridgehead amines are described using sequential ring-closing metathesis (RCM) and 5-exo-trig intramolecular radical cyclisation reactions. Critical… Expand
Rituximab for chronic inflammatory demyelinating polyneuropathy—A potential therapeutic option
Although there are a number of treatments that have been shown to be effective for chronic inflammatory demyelinating polyneuropathy (CIDP), over two thirds of patients require ongoing, indefinite… Expand
The hand in mixed connective tissue disease.
The mixed connective tissue disease syndrome has been described in the medical literature. The clinical and serological characteristics of the syndrome are defined in this paper. The hands of these… Expand
High Valent First Row Metals and Metal-Metal Bonds Supported by a Ketimide Ligand
- R. Lewis
Stem Cells for ALS: Anxiously Awaiting a Clear Signal of Efficacy
- R. Lewis
- 16 October 2018
In a phase II trial, 64 patients with mild-to-moderate amyotrophic lateral sclerosis (ALS; ALS Functional Rating Scale-Revised [ALSFRS-R] scores,
ROCK inhibitors show promise in glaucoma treatment
A novel class of drugs ‒ rho-kinase, or ROCK inhibitors ‒ appears to lower IOP by relaxing the trabecular meshwork.