• Publications
  • Influence
Structure of a protein superfiber: spider dragline silk.
  • M. Xu, R. Lewis
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 September 1990
Spider major ampullate (dragline) silk is an extracellular fibrous protein with unique characteristics of strength and elasticity. The silk fiber has been proposed to consist of pseudocrystallineExpand
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Isolation of a clone encoding a second dragline silk fibroin. Nephila clavipes dragline silk is a two-protein fiber.
  • M. Hinman, R. Lewis
  • Medicine, Biology
  • The Journal of biological chemistry
  • 25 September 1992
Spider dragline silk is a unique protein fiber possessing both high tensile strength and high elasticity. A partial cDNA clone for one dragline silk protein (Spidroin 1) was previously isolated.Expand
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Hypotheses that correlate the sequence, structure, and mechanical properties of spider silk proteins.
Several types of silks and silk protein coding genes have been characterized from orb-web weaving spiders. When the protein sequences of major ampullate, minor ampullate, and flagelliform silks fromExpand
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Molecular and mechanical characterization of aciniform silk: uniformity of iterated sequence modules in a novel member of the spider silk fibroin gene family.
Araneoid spiders use specialized abdominal glands to produce up to seven different protein-based silks/glues that have diverse physical properties. The fibroin sequences that encode aciniform fibersExpand
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Evidence from flagelliform silk cDNA for the structural basis of elasticity and modular nature of spider silks.
Orb-web weaving spiders rely on their aerial nets to entrap flying prey. A key mechanical feature of orb-web design is the high elasticity of the capture spiral. We report the cloning of substantialExpand
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Statistical determination of the average values of the extinction coefficients of tryptophan and tyrosine in native proteins.
Spectroscopic measurement of protein concentration requires knowledge of the value of the relevant extinction coefficient. If the amino acid composition of a protein is known, however, extinctionExpand
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Role of pH and charge on silk protein assembly in insects and spiders
Silk fibers possess impressive mechanical properties, dependant, in part, on the crystalline β-sheets silk II conformation. The transition to silk II from soluble silk I-like conformation in silkExpand
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Spider minor ampullate silk proteins contain new repetitive sequences and highly conserved non‐silk‐like “spacer regions”
  • M. Colgin, R. Lewis
  • Biology, Medicine
  • Protein science : a publication of the Protein…
  • 1 March 1998
Spider minor ampullate silk is a strong non‐elastic deformably stretchable silk used in web formation. This silk from Nephila clavipes is composed of two proteins, MiSp 1 and 2, whose transcripts areExpand
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Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties
  • F. Teulé, Y. Miao, +5 authors D. Jarvis
  • Materials Science, Medicine
  • Proceedings of the National Academy of Sciences
  • 3 January 2012
The development of a spider silk-manufacturing process is of great interest. However, there are serious problems with natural manufacturing through spider farming, and standard recombinant proteinExpand
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