R. Lerchundi

Publications15
h-index11
Citations811
Highly Influential Citations36
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A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells
Lactate is shuttled between and inside cells, playing metabolic and signaling roles in healthy tissues. Lactate is also a harbinger of altered metabolism and participates in the pathogenesis of… Expand
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Imaging Mitochondrial Flux in Single Cells with a FRET Sensor for Pyruvate
Mitochondrial flux is currently accessible at low resolution. Here we introduce a genetically-encoded FRET sensor for pyruvate, and methods for quantitative measurement of pyruvate transport,… Expand
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Channel-Mediated Lactate Release by K+-Stimulated Astrocytes
Excitatory synaptic transmission is accompanied by a local surge in interstitial lactate that occurs despite adequate oxygen availability, a puzzling phenomenon termed aerobic glycolysis. In addition… Expand
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NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K+
Excitatory synaptic transmission stimulates brain tissue glycolysis. This phenomenon is the signal detected in FDG-PET imaging and, through enhanced lactate production, is also thought to contribute… Expand
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Neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1.
Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) belong to the family Herpesviridae, the subfamily Alphaherpesvirinae, and the genus Simplexvirus. They are ubiquitous,… Expand
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Impaired Brain Energy Metabolism in the BACHD Mouse Model of Huntington's Disease: Critical Role of Astrocyte–Neuron Interactions
Huntington's disease (HD) is caused by cytosine-adenine-guanine (CAG) repeat expansions in the huntingtin (Htt) gene. Although early energy metabolic alterations in HD are likely to contribute to… Expand
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NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting
Significance Aerobic glycolysis is important for synaptic growth, neuronal excitability, memory formation, and behavior and is also involved in neurodegeneration. Here we present evidence, obtained… Expand
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Tau cleavage at D421 by caspase-3 is induced in neurons and astrocytes infected with herpes simplex virus type 1.
Herpes Simplex Virus Type 1 (HSV-1) is ubiquitous, neurotropic, and the most common pathogenic causes of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high… Expand
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Single-cell imaging tools for brain energy metabolism: a review
Abstract. Neurophotonics comes to light at a time in which advances in microscopy and improved calcium reporters are paving the way toward high-resolution functional mapping of the brain. This review… Expand
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Small is fast: astrocytic glucose and lactate metabolism at cellular resolution
Brain tissue is highly dynamic in terms of electrical activity and energy demand. Relevant energy metabolites have turnover times ranging from milliseconds to seconds and are rapidly exchanged… Expand
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