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- Publications
- Influence
A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells
- A. San Martín, S. Ceballo, I. Ruminot, R. Lerchundi, W. Frommer, L. Barros
- Biology, Medicine
- PloS one
- 26 February 2013
Lactate is shuttled between and inside cells, playing metabolic and signaling roles in healthy tissues. Lactate is also a harbinger of altered metabolism and participates in the pathogenesis of… Expand
Imaging Mitochondrial Flux in Single Cells with a FRET Sensor for Pyruvate
- A. San Martín, S. Ceballo, +5 authors L. Barros
- Biology, Medicine
- PloS one
- 21 January 2014
Mitochondrial flux is currently accessible at low resolution. Here we introduce a genetically-encoded FRET sensor for pyruvate, and methods for quantitative measurement of pyruvate transport,… Expand
Channel-Mediated Lactate Release by K+-Stimulated Astrocytes
- T. Sotelo-Hitschfeld, M. I. Niemeyer, +18 authors L. Barros
- Biology, Medicine
- The Journal of Neuroscience
- 11 March 2015
Excitatory synaptic transmission is accompanied by a local surge in interstitial lactate that occurs despite adequate oxygen availability, a puzzling phenomenon termed aerobic glycolysis. In addition… Expand
NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K+
- I. Ruminot, R. Gutiérrez, +6 authors L. Barros
- Biology, Medicine
- The Journal of Neuroscience
- 5 October 2011
Excitatory synaptic transmission stimulates brain tissue glycolysis. This phenomenon is the signal detected in FDG-PET imaging and, through enhanced lactate production, is also thought to contribute… Expand
Neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1.
- A. Zambrano, L. Solís, Natalia A Salvadores, M. Cortés, R. Lerchundi, C. Otth
- Biology, Medicine
- Journal of Alzheimer's disease : JAD
- 2008
Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) belong to the family Herpesviridae, the subfamily Alphaherpesvirinae, and the genus Simplexvirus. They are ubiquitous,… Expand
Impaired Brain Energy Metabolism in the BACHD Mouse Model of Huntington's Disease: Critical Role of Astrocyte–Neuron Interactions
- L. Boussicault, A. Hérard, +15 authors G. Bonvento
- Biology, Medicine
- Journal of cerebral blood flow and metabolism…
- 1 September 2014
Huntington's disease (HD) is caused by cytosine-adenine-guanine (CAG) repeat expansions in the huntingtin (Htt) gene. Although early energy metabolic alterations in HD are likely to contribute to… Expand
NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting
- R. Lerchundi, I. Fernández-Moncada, +8 authors L. Barros
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 18 August 2015
Significance Aerobic glycolysis is important for synaptic growth, neuronal excitability, memory formation, and behavior and is also involved in neurodegeneration. Here we present evidence, obtained… Expand
Tau cleavage at D421 by caspase-3 is induced in neurons and astrocytes infected with herpes simplex virus type 1.
- R. Lerchundi, R. Neira, +4 authors C. Otth
- Biology, Medicine
- Journal of Alzheimer's disease : JAD
- 2011
Herpes Simplex Virus Type 1 (HSV-1) is ubiquitous, neurotropic, and the most common pathogenic causes of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high… Expand
Single-cell imaging tools for brain energy metabolism: a review
- A. San Martín, T. Sotelo-Hitschfeld, +9 authors L. Barros
- Biology, Medicine
- Neurophotonics
- 1 July 2014
Abstract. Neurophotonics comes to light at a time in which advances in microscopy and improved calcium reporters are paving the way toward high-resolution functional mapping of the brain. This review… Expand
Small is fast: astrocytic glucose and lactate metabolism at cellular resolution
- L. F. Barros, A. San Martín, +9 authors D. Espinoza
- Biology, Medicine
- Front. Cell. Neurosci.
- 22 March 2013
Brain tissue is highly dynamic in terms of electrical activity and energy demand. Relevant energy metabolites have turnover times ranging from milliseconds to seconds and are rapidly exchanged… Expand