• Publications
  • Influence
Long-Term Experimental Evolution in Escherichia coli. I. Adaptation and Divergence During 2,000 Generations
We assess the degree to which adaptation to a uniform environment among independently evolving asexual populations is associated with increasing divergence of those populations. In addition, we areExpand
Genome evolution and adaptation in a long-term experiment with Escherichia coli
The relationship between rates of genomic evolution and organismal adaptation remains uncertain, despite considerable interest. The feasibility of obtaining genome sequences from experimentallyExpand
Long-term experimental evolution in Escherichia coli
-We assess the degree to which adaptation to a uniform environment among independently evolving asexual populations is associated with increasing divergence of those populations. In addition, we areExpand
The fate of competing beneficial mutations in an asexual population
In sexual populations, beneficial mutations that occur in different lineages may be recombined into a single lineage. In asexual populations, however, clones that carry such alternative beneficialExpand
Microbial genetics: Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation
Microorganisms have been mutating and evolving on Earth for billions of years. Now, a field of research has developed around the idea of using microorganisms to study evolution in action. ControlledExpand
Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations.
We followed evolutionary change in 12 populations of Escherichia coli propagated for 10,000 generations in identical environments. Both morphology (cell size) and fitness (measured in competitionExpand
The Black Queen Hypothesis: Evolution of Dependencies through Adaptive Gene Loss
ABSTRACT Reductive genomic evolution, driven by genetic drift, is common in endosymbiotic bacteria. Genome reduction is less common in free-living organisms, but it has occurred in the numericallyExpand
Long-Term Dynamics of Adaptation in Asexual Populations
The Fit Get Fitter Advances in modern biology have allowed us to measure evolutionary fitness and estimate the rate of fixation of beneficial mutations. Drawing on the Long-Term Evolution Experiment,Expand
Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli
The role of historical contingency in evolution has been much debated, but rarely tested. Twelve initially identical populations of Escherichia coli were founded in 1988 to investigate this issue.Expand
Linking genetic change to community evolution: insights from studies of bacteria and bacteriophage
A major goal of community ecology is to link biological processes at lower scales with community patterns. Microbial communities are especially powerful model systems for making these links. In thisExpand
...
1
2
3
4
5
...