oskar organizes the germ plasm and directs localization of the posterior determinant nanos
- A. Ephrussi, L. K. Dickinson, R. Lehmann
- BiologyCell
- 12 July 1991
Induction of germ cell formation by oskar
- A. Ephrussi, R. Lehmann
- BiologyNature
- 30 July 1992
The oskar gene directs germ plasm assembly and controls the number of germ cell precursors formed at the posterior pole of the Drosophila embryo. Mislocalization of oskar RNA to the anterior pole…
Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells.
- A. Forbes, R. Lehmann
- BiologyDevelopment
- 15 February 1998
It is shown that maternally deposited Nanos protein is essential for germ cell migration, and suggested that, in contrast to embryonic patterning, Nanos and Pumilio may interact with different partners in the germline.
Regulation of zygotic gene expression in Drosophila primordial germ cells
- M. Doren, A. Williamson, R. Lehmann
- BiologyCurrent Biology
- 12 February 1998
Mechanisms guiding primordial germ cell migration: strategies from different organisms
- Brian E. Richardson, R. Lehmann
- BiologyNature reviews. Molecular cell biology
- 2010
The regulated migration of cells is essential for development and tissue homeostasis, and aberrant cell migration can lead to an impaired immune response and the progression of cancer. Primordial…
Nanos is the localized posterior determinant in Drosophila
- Charlotte I. Wang, R. Lehmann
- BiologyCell
- 23 August 1991
The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival
- K. Molyneaux, H. Zinszner, R. Lehmann
- BiologyDevelopment
- 15 September 2003
Results show that the SDF1/CXCR4 interaction is specifically required for the colonization of the gonads by primordial germ cells, but not for earlier stages in germ cell migration, demonstrating a high degree of evolutionary conservation of part of the mechanism, but also an area of evolutionary divergence.
Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate
- C. Navarro, H. Puthalakath, Jerry M. Adams, A. Strasser, R. Lehmann
- BiologyNature Cell Biology
- 11 April 2004
It is reported that Egl interacts directly with Drosophila dynein light chain (Dlc), a microtubule motor component, through an Egl domain distinct from that which binds BicD, and supports the hypothesis that microtubules-mediated transport is important for preserving oocyte fate.
piRNA Production Requires Heterochromatin Formation in Drosophila
- P. Rangan, C. Malone, R. Lehmann
- BiologyCurrent Biology
- 23 August 2011
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