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REDUCTION OF ACUTE INFLAMMATION IN RATS BY DIAZEPAM: ROLE OF PERIPHERAL BENZODIAZEPINE RECEPTORS AND CORTICOSTERONE
Carrageenin causes a reproducible inflammatory reaction and remains the standard irritant for examining acute inflammation and anti-inflammatory drugs. High doses of diazepam (10.0–20.0 mg/Kg) wereExpand
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Diazepam effects on carrageenan-induced inflammatory paw edema in rats: role of nitric oxide.
High doses of diazepam (10.0-20.0 mg/kg) were shown to reduce the volume of acute inflammatory paw edema in rats as a response to carrageenan administration. This effect was attributed to an actionExpand
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Effects of acute and long-term diazepam administrations on neutrophil activity: a flow cytometric study.
This study analyzed the effects of acute and long-term diazepam treatments on rat peripheral blood neutrophil activity and cortisol serum levels. Rats were acutely and long-term (21 days, once daily)Expand
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Reduction of inflammation in rats by diazepam: tolerance development.
High doses of diazepam (10-20 mg/kg) were shown to reduce the volume of acute carrageenan-induced inflammatory paw edema in rats. This effect was not observed after adrenalectomy or long-term use ofExpand
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Effects of single or repeated amphetamine treatment and withdrawal on lung allergic inflammation in rats.
The effects of single or repeated amphetamine (AMPH) treatment and those of AMPH withdrawals on immune-mediated lung inflammatory response were studied in rats. Two experiments were done. In theExpand
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Effects of high doses of diazepam on carrageenin-induced paw edema in rats.
Benzodiazepine (BDZ) receptor sites play a relevant role in immune/inflammatory reactions. Acute BDZ treatments were shown not only to suppress cell proliferation in rat thymus but also to decreaseExpand
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Effects of Amphetamine on Immune-Mediated Lung Inflammatory Response in Rats
Objective: The present study analyzed the effects of acute amphetamine (AMPH) treatment on immune-mediated lung inflammatory response in rats. Methods: There were four experiments. In the first andExpand
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Odor cues from tumor-bearing mice induces neuroimmune changes
Cohabitation for 14 days with an Ehrlich tumor-bearing mice was shown, among others, to increase locomotor activity, and hypothalamic noradrenaline levels and turnover, to decrease the innate immuneExpand
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Diazepam decreases leukocyte–endothelium interactions in situ
High doses of diazepam reduce the inflammatory paw edema in rats. This effect was attributed to an action of diazepam on the Translocator Protein (TSPO). We evaluated the effects of diazepam (10Expand
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