• Publications
  • Influence
Becoming a new neuron in the adult olfactory bulb
TLDR
The results show that newly born cells recruited into the olfactory bulb become neurons, and a unique sequence of events leads to their functional integration. Expand
Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration
TLDR
The results demonstrate that Eph-family receptor tyrosine kinases and their transmembrane ligands are involved in interactions between neural crest and sclerotomal cells, mediating an inhibitory activity necessary to constrain neural precursors to specific territories in the developing nervous system. Expand
Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching
TLDR
It is concluded that Ku70 is required for the generation of B cells that have undergone Ig HC class switching, and potential roles for Ku70 in the CSR process are discussed. Expand
A class switch control region at the 3′ end of the immunoglobulin heavy chain locus
TLDR
It is proposed that the 3'EH-/- mutation disrupts the activity of a regulatory region that influences heavy chain class switching to several different CH genes that lie as far as 100 kb upstream of the mutation. Expand
Imaging Cells in the Developing Nervous System with Retrovirus Expressing Modified Green Fluorescent Protein
TLDR
Repl replication-incompetent retroviral vectors encoding green fluorescent protein (GFP) that can be detected as a single integrated copy per cell are constructed and used to efficiently mark and follow the developmental progression of a large population of cells in rat neocortex and whole avian embryos. Expand
Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.
TLDR
Strikingly, simultaneous introduction of mu HC and lambda LC transgenes into RAG-2-/- mice led to the generation of a substantial population of "monoclonal" peripheral B-cells that were functional with regard to immunoglobulin secretion, indicating that T cells or diverse immunoglOBulin repertoires are not necessary for peripheral B -cell development. Expand
Multi-spectral imaging and linear unmixing add a whole new dimension to laser scanning fluorescence microscopy.
TLDR
Some approaches that have been used to enhance spectral resolution in fluorescence microscopy are reviewed, hoping to decipher multiple spectral signatures within cells and organisms, a process known as emission fingerprinting. Expand
Dynamic Analysis of Vascular Morphogenesis Using Transgenic Quail Embryos
TLDR
It is shown that during vasculogenesis within the vascular plexus, ECs move independently to form the rudiments of blood vessels, all while collectively moving with gastrulating tissues that flow toward the embryo midline. Expand
S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.
TLDR
It is demonstrated for the first time that, for optimal efficiency, the process requires the presence of the intact I region and/or I region promoter in cis, implicating factors beyond transcription through the S region in the regulation of class switching. Expand
Japanese quail (Coturnix japonica) as a laboratory animal model
TLDR
The authors describe the Japanese quail as an animal model and, drawing on their experience raising a quail colony at the California Institute of Technology, present detailed guidelines for the husbandry of the species. Expand
...
1
2
3
4
5
...