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Becoming a new neuron in the adult olfactory bulb
- A. Carleton, L. Petreanu, R. Lansford, A. Álvarez-Buylla, P. Lledo
- BiologyNature Neuroscience
- 1 May 2003
The results show that newly born cells recruited into the olfactory bulb become neurons, and a unique sequence of events leads to their functional integration.
Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration
Imaging Cells in the Developing Nervous System with Retrovirus Expressing Modified Green Fluorescent Protein
- Ami Okada, R. Lansford, J. Weimann, S. Fraser, S. Mcconnell
- BiologyExperimental Neurology
- 1 April 1999
Repl replication-incompetent retroviral vectors encoding green fluorescent protein (GFP) that can be detected as a single integrated copy per cell are constructed and used to efficiently mark and follow the developmental progression of a large population of cells in rat neocortex and whole avian embryos.
Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching
It is concluded that Ku70 is required for the generation of B cells that have undergone Ig HC class switching, and potential roles for Ku70 in the CSR process are discussed.
A class switch control region at the 3′ end of the immunoglobulin heavy chain locus
Multi-spectral imaging and linear unmixing add a whole new dimension to laser scanning fluorescence microscopy.
Some approaches that have been used to enhance spectral resolution in fluorescence microscopy are reviewed, hoping to decipher multiple spectral signatures within cells and organisms, a process known as emission fingerprinting.
Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.
Strikingly, simultaneous introduction of mu HC and lambda LC transgenes into RAG-2-/- mice led to the generation of a substantial population of "monoclonal" peripheral B-cells that were functional with regard to immunoglobulin secretion, indicating that T cells or diverse immunoglOBulin repertoires are not necessary for peripheral B -cell development.
Dynamic Analysis of Vascular Morphogenesis Using Transgenic Quail Embryos
It is shown that during vasculogenesis within the vascular plexus, ECs move independently to form the rudiments of blood vessels, all while collectively moving with gastrulating tissues that flow toward the embryo midline.
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.
- J. Chen, R. Lansford, V. Stewart, F. Young, F. Alt
- BiologyProceedings of the National Academy of Sciences…
- 15 May 1993
A system to evaluate the function of lymphocyte-specific and generally expressed genes in the differentiation and/orfunction of lymphocytes is described and rescues the JH-/- mutation and allows the generation of both mature T and mature B cells.
S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.
It is demonstrated for the first time that, for optimal efficiency, the process requires the presence of the intact I region and/or I region promoter in cis, implicating factors beyond transcription through the S region in the regulation of class switching.