Nanocarriers as an emerging platform for cancer therapy.
- D. Peer, J. Karp, Seungpyo Hong, O. Farokhzad, R. Margalit, R. Langer
- BiologyNature Nanotechnology
- 1 December 2007
The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
A tough biodegradable elastomer
- Yadong Wang, G. Ameer, B. Sheppard, R. Langer
- Biology, Materials ScienceNature Biotechnology
- 1 June 2002
A tough biodegradable elastomer is designed, synthesized, and characterized from biocompatible monomers that forms a covalently crosslinked, three-dimensional network of random coils with hydroxyl groups attached to its backbone.
Knocking down barriers: advances in siRNA delivery
An update on the progress of RNAi therapeutics is provided and novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids are highlighted.
Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review.
Drug delivery and targeting.
- R. Langer
- 30 April 1998
When a pharmaceutical agent is encapsulated within, or attached to, a polymer or lipid, drug safety and efficacy can be greatly improved and new therapies are possible. This has provided the impetus…
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
- O. Farokhzad, Jianjun Cheng, R. Langer
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 18 April 2006
The potential utility of nanoparticle-aptamer bioconjugates for a therapeutic application is demonstrated and remarkable efficacy and reduced toxicity as measured by mean body weight loss (BWL) in vivo are demonstrated.
Polymeric systems for controlled drug release.
Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
Designing materials for biology and medicine
New challenges and directions in biomaterials research are discussed, including synthetic replacements for biological tissues, designing materials for specific medical applications, and materials for new applications such as diagnostics and array technologies.
Transdermal drug delivery
Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound for delivery of macromolecules and vaccines.