Share This Author
Rivastigmine for dementia associated with Parkinson's disease.
Rivastigmine was associated with moderate improvements in dementia associated with Parkinson's disease but also with higher rates of nausea, vomiting, and tremor; however, the differences between these two groups were moderate and similar to those reported in trials of rivastIGmine for Alzheimer's disease.
Targeting acetylcholinesterase and butyrylcholinesterase in dementia.
New evidence for the roles of BuChE and AChE in symptom generation and rate of underlying disease progression in dementia is focused on, and it is argued that it may be appropriate to re-evaluate the place of ChE-Is in the treatment of dementia.
A six‐month double‐blind, randomized, placebo‐controlled study of a transdermal patch in Alzheimer's disease–– rivastigmine patch versus capsule
- B. Winblad, J. Cummings, R. Lane
- Medicine, PsychologyInternational journal of geriatric psychiatry
- 1 May 2007
To compare the efficacy, safety and tolerability of a novel rivastigmine transdermal patch with conventional rivastigmine capsules and placebo in patients with Alzheimer's disease (AD).
Effects of SSRIs on sexual function: a critical review.
The effects of SSRIs on sexual functioning seem strongly dose-related and may vary among the group according to serotonin and dopamine reuptake mechanisms, induction of prolactin release, anticholinergic effects, inhibition of nitric oxide synthetase, and propensity for accumulation over time.
Sertraline treatment of generalized social phobia: a 20-week, double-blind, placebo-controlled study.
- M. Van Ameringen, R. Lane, R. Swinson
- Psychology, MedicineThe American journal of psychiatry
- 1 February 2001
Sertraline is an effective treatment for patients with generalized social phobia and analysis of covariance showed superiority of sERTraline over placebo on all primary and secondary efficacy measures.
Targeting Huntingtin Expression in Patients with Huntington's Disease.
Intrathecal administration of HTTRx to patients with early Huntington's disease was not accompanied by serious adverse events and dose-dependent reductions in concentrations of mutant huntingtin were observed.
Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study
Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.
In adults with ALS due to SOD1 mutations, CSF S OD1 concentrations decreased at the highest concentration of tofersen administered intrathecally over a period of 12 weeks.
Selective serotonin reuptake inhibitor-induced serotonin syndrome: review.
To reduce the occurrence, morbidity, and mortality of the serotonin syndrome, it must be both prevented by prudent pharmacotherapy and given prompt recognition when it is present.
Behavioral symptoms in mild cognitive impairment
The authors investigated neuropsychiatric symptoms in mild cognitive impairment (MCI) from baseline data of the Investigation in the Delay to Diagnosis of AD with Exelon (InDDEx) study, finding that NPI+ subjects had significantly greater impairment on global, cognitive, and functional scores than NPI− subjects.