• Publications
  • Influence
Notch signaling: cell fate control and signal integration in development.
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis. Expand
UV-induced association of the CSB remodeling protein with chromatin requires ATP-dependent relief of N-terminal autorepression.
It is demonstrated that ATP hydrolysis by CSB is essential for stable CSB-chromatin association after UV irradiation and that defects in this association underlie some forms of Cockayne syndrome, and the N-terminal region of CSB negatively regulates chromatin association during normal cell growth. Expand
Rapid detection of Listeria monocytogenes in ham samples using immunomagnetic separation followed by polymerase chain reaction
A 24‐h system for the detection of Listeria monocytogenes in ham is developed to develop a 24-h system to detect the bacterium in ham. Expand
Crossing paths with Notch in the hyper-network.
The Notch pathway is a useful paradigm to illustrate the complexity of pathway cross-talk: its pervasiveness, context dependency, and importance in development and disease. Expand
RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking
The results raise the intriguing hypothesis that by collaborating with CTCF, RBPJ may participate in establishing chromatin domains and/or long-range chromatin interactions that could be propagated through cell division to maintain gene expression programs. Expand
ATP-Dependent Chromatin Remodeling by Cockayne Syndrome Protein B and NAP1-Like Histone Chaperones Is Required for Efficient Transcription-Coupled DNA Repair
It is shown that CSB repositions nucleosomes in an ATP–dependent manner in vitro and that this activity is greatly enhanced by the NAP1-like histone chaperones, which are identified as new CSB–binding partners. Expand
Structure, function and regulation of CSB: A multi-talented gymnast
  • R. Lake, H. Fan
  • Medicine, Biology
  • Mechanisms of Ageing and Development
  • 1 May 2013
Current knowledge of the structure, function and regulation of CSB is summarized, and how these properties can impact the biological functions of this chromatin remodeler is discussed. Expand
Modifiers of notch transcriptional activity identified by genome-wide RNAi
The genome-wide RNAi screen identified many genes that can modulate Notch transcriptional output, which opens new avenues to explore the mechanisms of Notch signal regulation and the integration of this pathway into diverse cellular processes. Expand
Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless
It is shown that changes in divalent cation concentrations lead to NICD self-association, which seems to be mediated by the polyglutamine-containing, opa-repeat region of NICD. Expand
In Vivo Analysis of the Notch Receptor S1 Cleavage
The results demonstrate a correlation between loss of cleavage and loss of in vivo function of the Notch receptor, supporting the notion that S1 cleavage is an in vivo mechanism of Notch signal control. Expand