Share This Author
Notch signaling: cell fate control and signal integration in development.
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.
UV-induced association of the CSB remodeling protein with chromatin requires ATP-dependent relief of N-terminal autorepression.
Crossing paths with Notch in the hyper-network.
RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking
The results raise the intriguing hypothesis that by collaborating with CTCF, RBPJ may participate in establishing chromatin domains and/or long-range chromatin interactions that could be propagated through cell division to maintain gene expression programs.
ATP-Dependent Chromatin Remodeling by Cockayne Syndrome Protein B and NAP1-Like Histone Chaperones Is Required for Efficient Transcription-Coupled DNA Repair
It is shown that CSB repositions nucleosomes in an ATP–dependent manner in vitro and that this activity is greatly enhanced by the NAP1-like histone chaperones, which are identified as new CSB–binding partners.
Structure, function and regulation of CSB: A multi-talented gymnast
Modifiers of notch transcriptional activity identified by genome-wide RNAi
- P. Mourikis, R. Lake, Christopher Firnhaber, B. DeDecker
- BiologyBMC Developmental Biology
- 19 October 2010
The genome-wide RNAi screen identified many genes that can modulate Notch transcriptional output, which opens new avenues to explore the mechanisms of Notch signal regulation and the integration of this pathway into diverse cellular processes.
The promises and pitfalls of sex integration in sport and physical culture
- A. Channon, Katherine Dashper, T. Fletcher, R. Lake
- EducationSex Integration in Sport and Physical Culture
- 20 October 2016
Scholars working in the academic field of sport studies have long debated the relationship between modern sport and gender (e.g., Hargreaves and Anderson, 2014; Hargreaves, 1994; Lenskyj, 1986;…
Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless
- Deborah F. Kelly, R. Lake, T. Walz, S. Artavanis-Tsakonas
- BiologyProceedings of the National Academy of Sciences
- 5 June 2007
It is shown that changes in divalent cation concentrations lead to NICD self-association, which seems to be mediated by the polyglutamine-containing, opa-repeat region of NICD.
In Vivo Analysis of the Notch Receptor S1 Cleavage
The results demonstrate a correlation between loss of cleavage and loss of in vivo function of the Notch receptor, supporting the notion that S1 cleavage is an in vivo mechanism of Notch signal control.