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Anti-infection Peptidomics of Amphibian Skin *S
  • J. Li, X. Xu, +9 authors J. Wu
  • Biology, Medicine
  • Molecular & Cellular Proteomics
  • 1 May 2007
Peptidomics and genomics analyses were used to study an anti-infection array of peptides of amphibian skin. 372 cDNA sequences of antimicrobial peptides were characterized from a single individualExpand
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Snake Cathelicidin from Bungarus fasciatus Is a Potent Peptide Antibiotics
Background Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules of innate immunity, which are firstly found in mammalians. Recently, several cathelicidinsExpand
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Chemical Punch Packed in Venoms Makes Centipedes Excellent Predators*
Centipedes are excellent predatory arthropods that inject venom to kill or immobilize their prey. Although centipedes have long been known to be venomous, their venoms remain largely unexplored. TheExpand
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Structure of Protein Having Inhibitory Disintegrin and Leukotriene Scavenging Functions Contained in Single Domain*
Background: Tablysin-15 from a blood-feeding arthropod binds integrins. Results: The structure of tablysin-15 reveals a hydrophobic channel in addition to a canonical integrin-binding RGD motif.Expand
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Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models
Significance The economic burden of chronic pain in the United States is currently ∼$600 billion per annum, which exceeds the combined annual cost of cancer, heart disease, and diabetes. Few drugsExpand
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A Novel Non-Lens βγ−Crystallin and Trefoil Factor Complex from Amphibian Skin and Its Functional Implications
Background In vertebrates, non-lens βγ-crystallins are widely expressed in various tissues, but their functions are unknown. The molecular mechanisms of trefoil factors, initiators of mucosal healingExpand
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Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
Two groups of antimicrobial peptides have been isolated from skin secretions of Bombina maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-likeExpand
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Two novel non-cationic defensin-like antimicrobial peptides from haemolymph of the female tick, Amblyomma hebraeum.
Two non-cationic defensin-like antimicrobial peptides, named Amblyomma defensin peptide 1 and Amblyomma defensin peptide 2, were identified from the hard tick, Amblyomma hebraeum, by a combination ofExpand
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Antioxidant Peptidomics Reveals Novel Skin Antioxidant System*S
It is generally agreed that reactive oxygen species (ROS) contribute to skin aging, skin disorders, and skin diseases. Skin possesses an extremely efficient antioxidant system. This antioxidantExpand
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Two Immunoregulatory Peptides with Antioxidant Activity from Tick Salivary Glands*
Ticks are blood-feeding arthropods that may secrete immunosuppressant molecules, which inhibit host inflammatory and immune responses and provide survival advantages to pathogens at tick bleedingExpand
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