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Revised age estimates of Australopithecus-bearing deposits at Sterkfontein, South Africa.
TLDR
The interpretation of the fauna, the archeometric results, and the magnetostratigraphy of Sterkfontein indicate that it is unlikely that any Members yet described from SterkFontein are in excess of 3.04 Ma in age, and it is suggested that Australopithecus africanus should not be considered as a temporal contemporary of Australopheticcus afarensis, Australopheses bahrelghazali, and Kenyanthropus platyops. Expand
Lamellar Bone is an Incremental Tissue Reconciling Enamel Rhythms, Body Size, and Organismal Life History
TLDR
This study examines the relationship among long-period enamel rhythms, the striae of Retzius, and body mass using a large sample of mammalian taxa to seek a rhythm in bone growth demonstrably related to enamel oscillatory development and confirms that lamellar bone is an incremental tissue. Expand
Primate enamel evinces long period biological timing and regulation of life history.
TLDR
It is suggested here that a biological rhythm with a period greater than the circadian rhythm is responsible for observed variation in primate life history, and a mathematical model is proposed that may help elucidate the underlying physiological mechanism responsible for the Havers-Halberg Oscillation. Expand
Dental enamel hypoplasia, age at death, and weaning in the Taung child
TLDR
It is suggested that the age at death of the Taung child was between 3.73 and 3.93 years, just slightly later than previously proposed. Expand
Diseases caused by mutations in ORAI1 and STIM1
  • R. Lacruz, S. Feske
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 November 2015
TLDR
The cellular dysfunction and clinical disease spectrum observed in mutant patients provide important information about the molecular regulation of ORAI1 and STIM1 proteins and the role of CRAC channels in human physiology. Expand
Regulation of pH During Amelogenesis
TLDR
The intra- and extracellular mechanisms employed by the enamel-forming cells, ameloblasts, to maintain pH homeostasis are summarized and the enameless phenotypes associated with disruptions to genes involved in pH regulation are discussed. Expand
New Paradigms on the Transport Functions of Maturation-stage Ameloblasts
TLDR
The main cellular activities of these genes during the maturation stage of amelogenesis are described, which include ion transport and storage, control of intracellular and extracellular pH, and endocytosis. Expand
Adaptor protein complex 2–mediated, clathrin‐dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis
TLDR
Using real‐time PCR, it is shown that the expression of clathrin and adaptor protein subunits are upregulated in maturation stage rodent enamel organ cells, supporting the existence of a membrane‐bound receptor‐regulated pathway for the endocytosis of enamel matrix proteins. Expand
Megadontia, striae periodicity and patterns of enamel secretion in Plio‐Pleistocene fossil hominins
TLDR
Daily enamel increments and periodicity values are measured in 17 molars of Plio‐Pleistocene hominins representing seven different species, including specimens attributed to early Homo to provide a better framework to interpret surface manifestations of internal growth markings on fossil hominin tooth crowns. Expand
Palaeontology and geological context of a Middle Pleistocene faunal assemblage from the Gladysvale Cave, South Africa
Palaeo-Anthropology Scientific Trust; French Embassy in South Africa; Co-operation and Cultural Service; National Geographic Society; John Nash and family; DACEL; University of the WitwatersrandExpand
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