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Statin-Induced Inhibition of MCF-7 Breast Cancer Cell Proliferation is Related to Cell Cycle Arrest and Apoptotic and Necrotic Cell Death Mediated by an Enhanced Oxidative Stress
TLDR
The results suggest that the cytotoxic effect observed is mediated by an oxidative stress. Expand
Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter.
TLDR
The activation of HUVEC induced by PM(2.5) and PM(10) is related with an oxidative stress, suggesting that these particles may participate in the development of cardiovascular and inflammatory diseases. Expand
Statins Inhibit the Proliferation and Induce Cell Death of Human Papilloma Virus Positive and Negative Cervical Cancer Cells
TLDR
The results suggest that statins exert anti-tumoral effects on cervical cancer through inhibition of cell proliferation and induction of cell death and oxidative stress, and could be an aid in the treatment of cervical cancer. Expand
Autocrine/paracrine erythropoietin signalling promotes JAK/STAT‐dependent proliferation of human cervical cancer cells
TLDR
The results are consistent with the existence of a functional, endogenous Epo/EpoR system in cervical cancer with the capacity to activate the transduction of signals resulting in an increased proliferation potential. Expand
Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells.
TLDR
TiO2 NPs induced a strong oxidative stress in both glial cell lines by mediating changes in the cellular redox state and lipid peroxidation associated with a rise in the expression of glutathione peroxidase, catalase, and superoxide dismutase 2, indicating toxicity. Expand
TiO₂ nanoparticles induce dysfunction and activation of human endothelial cells.
TLDR
TiO₂ induced HUVEC activation, inhibition of cell proliferation with increased cell death, and oxidative stress, which were associated with oxidative stress and NF-κB pathway activation. Expand
Effects of dehydroepiandrosterone on proliferation, migration, and death of breast cancer cells.
TLDR
The results suggest that the mechanism of D HEA actions against breast cancer involves the inhibition of cell proliferation and the suppression of migration, indicating that DHEA could be useful in the treatment of breast cancer. Expand
Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis.
TLDR
C8-ceramide markedly reduced the tumor cell number after 48 h of treatment, an effect that endured even after the removal of C8- Aceramide, and the possible application of ceramide in the treatment of early stages of cervical cancer is discussed. Expand
PM2.5 and PM10 Induce the Expression of Adhesion Molecules and the Adhesion of Monocytic Cells to Human Umbilical Vein Endothelial Cells
TLDR
PM2.5 and PM10 induce the activation of HUVEC, leading to monocytic adhesion via the expression of adhesion molecules, suggesting that these particles may participate in the development of inflammatory diseases. Expand
The alpha-mangostin prevention on cisplatin-induced apoptotic death in LLC-PK1 cells is associated to an inhibition of ROS production and p53 induction.
TLDR
The preventive effect of alpha-M on CDDP-induced apoptotic death is associated to the inhibition of p53 expression and ROS generation. Expand
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