Skip to search formSkip to main contentSkip to account menu
  • Publications
  • Influence
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
TLDR
It is concluded that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.
View on Nature
Plexin-B1 Directly Interacts with PDZ-RhoGEF/LARG to Regulate RhoA and Growth Cone Morphology
View on Elsevier
Central mechanisms of pathological pain
  • R. Kuner
  • Biology
    Nature Medicine
  • 1 November 2010
TLDR
This review focuses on the molecular determinants of network plasticity in the central nervous system (CNS) and discusses their relevance to the development of new therapeutic approaches.
View on Nature
Role of heteromer formation in GABAB receptor function.
TLDR
The interaction of these receptors appears to be crucial for important physiological effects of GABA and provides a mechanism in receptor signaling pathways that involve a heterotrimeric GTP-binding protein.
View on PubMed
The AMPA Receptor Subunits GluR-A and GluR-B Reciprocally Modulate Spinal Synaptic Plasticity and Inflammatory Pain
View on Elsevier
Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia
TLDR
The generation of transgenic mouse lines which express Cre recombinase selectively in sensory ganglia using promoter elements of the Nav1.8 gene enable selective deletion of genes in subsets of sensory neurons and offer a wide scope for studying potential functions of genesIn pain perception, independent of secondary effects arising from developmental defects or global gene ablation.
View on Wiley
A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing
View on Elsevier
Plexin-B1/RhoGEF–mediated RhoA activation involves the receptor tyrosine kinase ErbB-2
TLDR
It is shown that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2 and that Erb B-2–mediated phosphorylation of plexIn-B1 is critically involved in Sema4D-induced RhoA activation, which underlies cellular phenomena downstream of pLexin- B1, including axonal growth cone collapse.
View PDF
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1
TLDR
Cdk5-mediated TRPV1 phosphorylation is important in the regulation of pain signaling, and inhibition of Cdk5 activity in cultured dorsal root ganglia neurons resulted in a significant reduction of TRpV1-mediated calcium influx, and this effect could be reversed by restoring Cdk4 activity.
View on Publisher
Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain
TLDR
Results show that G- CSF and GM-CSF are important in tumor-nerve interactions and suggest that their receptors on primary afferent nerve fibers constitute potential therapeutic targets in cancer pain.
View on Nature
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License