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Evolution of genes and genomes on the Drosophila phylogeny
TLDR
These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Expand
Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence
TLDR
It is proposed that it is not cross-overs per se that are mutagenic, but rather repair of DNA double-strand break precursors via crossing over and gene conversion, which is far stronger predictors of both diversity and interspecies difference than broad-scale estimates. Expand
Evolution in the Fast Lane: Rapidly Evolving Sex-Related Genes in Drosophila
TLDR
A relatively high proportion of SRR genes have experienced accelerated divergence throughout the genus Drosophila, and several testis-specific genes, male seminal fluid proteins (SFPs), and spermatogenesis genes show lineage-specific bursts of accelerated evolution and positive selection. Expand
The Genomics of Speciation in Drosophila: Diversity, Divergence, and Introgression Estimated Using Low-Coverage Genome Sequencing
TLDR
It is concluded that chromosomal rearrangements have been vital to the ongoing persistence of these species despite recent hybridization and serves as a proof-of-principle on how whole genome sequencing can be applied to formulate and test hypotheses about species formation in lesser-known non-model systems. Expand
Bayesian Analysis Suggests that Most Amino Acid Replacements in Drosophila Are Driven by Positive Selection
TLDR
It is found that there is no evidence that a significant fraction of fixed amino acid replacements is neutral or nearly neutral or that positive selection drives amino acid replacement sites at only a subset of the loci. Expand
Mammalian sperm proteins are rapidly evolving: evidence of positive selection in functionally diverse genes.
TLDR
It is shown that genes expressed solely in spermatozoa represent a highly diverged subset among mouse and human tissue-specific orthologs, and the molecular action of sexual selection on a variety of characters involved in mammalian sperm function is highlighted. Expand
Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes.
TLDR
Direct genome-wide searches for unusual protein-coding structures are performed, discovering 149 possible examples of stop codon readthrough, 125 new candidate ORFs of polycistronic mRNAs, and several candidate translational frameshifts. Expand
Hybridization Reveals the Evolving Genomic Architecture of Speciation
TLDR
Comparing full genome sequences of 32 butterflies, representing five species from a hybridizing Heliconius butterfly community, to examine genome-wide patterns of introgression and infer how divergence evolves during the speciation process provides a uniquely comprehensive portrait of the evolving species boundary. Expand
The B-type lamin is required for somatic repression of testis-specific gene clusters
TLDR
These studies, which directly link nuclear architecture with coordinated regulation of tissue-specific genes, advance understanding of the mechanisms underlying both normal cell differentiation and developmental disorders caused by lesions in the B-type lamins and interacting proteins. Expand
Population Genomic Inferences from Sparse High-Throughput Sequencing of Two Populations of Drosophila melanogaster
TLDR
Simulations and empirical results suggest that nucleotide diversity can be accurately estimated from sparse data with as little as 0.2× coverage per line, and demonstrates that short-read sequencing methods provide an efficient means to quantify variation in genome organization and content. Expand
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