A structural perspective of the flavivirus life cycle
- S. Mukhopadhyay, R. Kuhn, M. Rossmann
- BiologyNature Reviews Microbiology
- 2005
The structural organization of these viruses and their associated structural proteins has provided insight into the molecular transitions that occur during the viral life cycle, such as assembly, budding, maturation and fusion.
Structure of Dengue Virus Implications for Flavivirus Organization, Maturation, and Fusion
- R. Kuhn, Wei Zhang, J. H. Strauss
- BiologyCell
- 8 March 2002
Visualization of membrane protein domains by cryo-electron microscopy of dengue virus
- Wei Zhang, P. Chipman, R. Kuhn
- BiologyNature Structural Biology
- 5 October 2003
The structure of mature dengue virus particles was determined to a resolution of 9.5 Å by cryo-EM and image reconstruction techniques, establishing the secondary structural disposition of the 180 envelope (E) and 180 membrane (M) proteins in the lipid envelope.
The 3.8 Å resolution cryo-EM structure of Zika virus
- Devika Sirohi, Zhenguo Chen, R. Kuhn
- BiologyScience
- 31 March 2016
The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors that suggests that differences in this region may influence virus transmission and disease.
Solution structure of dengue virus capsid protein reveals another fold.
- Lixin Ma, Christopher T. Jones, Teresa D Groesch, R. Kuhn, C. Post
- ChemistryProceedings of the National Academy of Sciences…
- 9 March 2004
A model for the interaction of dengue C protein with RNA and the viral membrane is proposed that is based on the asymmetric charge distribution of the protein and is consistent with previously reported results.
The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation.
- K. Choi, J. Groarke, M. Rossmann
- BiologyProceedings of the National Academy of Sciences…
- 30 March 2004
The structure of BVDV polymerase complexed with GTP, which is required for de novo (primer-independent) initiation, shows that GTP binds adjacent to the initiation NTP, suggesting that the GTP mimics aigial RNA product.
Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis
- N. Heaton, R. Perera, G. Randall
- BiologyProceedings of the National Academy of Sciences
- 20 September 2010
Mechanistic insight into DENV membrane remodeling is provided and the potential for the development of therapeutics that inhibit DENV replication by targeting the fatty acid biosynthetic pathway is highlighted.
Structures of immature flavivirus particles
- Ying Zhang, J. Corver, M. Rossmann
- ChemistryEMBO Journal
- 1 June 2003
Structures of prM‐containing dengue and yellow fever virus particles were determined to 16 and 25 Å resolution by cryoelectron microscopy and image reconstruction techniques, consistent with the predicted membrane‐spanning domains of the unprocessed polyprotein.
Structure of West Nile Virus
- S. Mukhopadhyay, Bong-Suk Kim, P. Chipman, M. Rossmann, R. Kuhn
- MedicineScience
- 10 October 2003
West Nile virus (WNV) is found throughout Africa, Europe, Central Asia, and, most recently, in North America, where there were 4156 outbreaks in 2002.
Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System
- D. Akey, W. C. Brown, Janet L. Smith
- BiologyScience
- 21 February 2014
Two-Faced Viral Protein Flaviviruses cause human diseases such as West Nile fever and dengue fever. The flavivirus nonstructural protein 1 (NS1) has multiple functions in flavivirus biology and is a…
...
...