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Hox genes in vertebrate development
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Homeobox genes and axial patterning
William McGinnis* and Robb Krumiauft *Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511 tNationai institute for Medical Research Mill Hill London NW7Expand
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Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
Comparison of Hoxb-1 regulatory regions from different vertebrates identified three related sequence motifs critical for rhombomere 4 (r4) expression in the hindbrain. Functional analysis inExpand
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Patterning the Vertebrate Neuraxis
Neuraxial patterning is a continuous process that extends over a protracted period of development. During gastrulation a crude anteroposterior pattern, detectable by molecular markers, is conferredExpand
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Initiation of Rhombomeric Hoxb4 Expression Requires Induction by Somites and a Retinoid Pathway
Anteroposterior (AP) patterning in the vertebrate hindbrain is dependent upon the establishment of segmental domains of Hox expression. We investigated the mechanism that governs the early expressionExpand
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Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
SEGMENTATION of the vertebrate hindbrain into rhombomeres is important for the anterior–posterior arrangement of cranial motor nuclei and efferent nerves1. Underlying this reiterated organization,Expand
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Wise, a context-dependent activator and inhibitor of Wnt signalling
We have isolated a novel secreted molecule, Wise, by a functional screen for activities that alter the anteroposterior character of neuralised Xenopus animal caps. Wise encodes a secreted proteinExpand
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Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II
ABSTRACT A common landmark of activated genes is the presence of trimethylation on lysine 4 of histone H3 (H3K4) at promoter regions. Set1/COMPASS was the founding member and is the only H3K4Expand
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Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups.
Initiation of Hox genes requires interactions between numerous factors and signaling pathways in order to establish their precise domain boundaries in the developing nervous system. There areExpand
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Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.
Neural progenitor cells often produce distinct types of neurons in a specific order, but the determinants that control the sequential generation of distinct neuronal subclasses in the vertebrate CNSExpand
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