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Central Autonomic Dysfunction Following Acquired Brain Injury in Children
The characteristics of children who had central autonomic dys function (CAD) after acquired brain injury are described, which complicates the management of these patients, reflects more severe injury, is usually associated with less favorable outcome, and can seriously inter fere with rehabilitation programs. Expand
GMFM 1 year after continuous intrathecal baclofen infusion
Assessment of motor function in persons with cerebral palsy who have had a reduction of muscle tone by continuous intrathecal baclofen infusion found that motor control, positioning and endurance improved. Expand
Home use of rectal diazepam for cluster and prolonged seizures: efficacy, adverse reactions, quality of life, and cost analysis.
- R. Kriel, J. Cloyd, R. Hadsall, A. Carlson, K. Floren, C. Jones-Saete
- Pediatric neurology
Improvements in quality of life associated with the availability of R-DZP were observed by 58% of users and 27% of nonusers which included improved management of their children's seizures, increased flexibility in family activities, and greater peace of mind. Expand
A pilot study assessing the bioavailability and pharmacokinetics of diazepam after intranasal and intravenous administration in healthy volunteers
The results of this pilot study indicate that development of an intranasal diazepam formulation with high bioavailability, reasonable variability, and good tolerability is feasible. Expand
Closed head injury: comparison of children younger and older than 6 years of age.
Results do not support the hypothesis that the youngest children have the best recovery after profound closed head injury, and children 6 years of age and older had better cognitive, motor, and brain atrophy outcomes than younger patients for each referral origin. Expand
Treating repetitive seizures with a rectal diazepam formulation
- J. Cereghino, W. Mitchell, J. Murphy, R. Kriel, W. Rosenfeld, E. Trevathan
- 1 November 1998
A single rectal dose of Diastat was significantly more effective than placebo in reducing the number of seizures following an episode of ARS, suggesting that caregivers could administer treatment safely and effectively in a nonmedical setting. Expand
Valproic acid pharmacokinetics in children. IV. Effects of age and antiepileptic drugs on protein binding and intrinsic clearance
- J. Cloyd, J. Fischer, R. Kriel, D. M. Kraus
- Clinical pharmacology and therapeutics
- 1 January 1993
The effect of age and polytherapy on valproate clearance is primarily attributable to changes in metabolism rather than in protein binding, and dosage requirements are greater and more variable for children who are receiving other enzyme‐inducing antiepileptic drugs. Expand
Hip status in cerebral palsy after one year of continuous intrathecal baclofen infusion.
Changes in muscle tone by continuous intrathecal baclofen infusion affects the progression of hip subluxation in persons with cerebral palsy and were not associated with the subject's age or the severity of cerebral palsies. Expand
An Open‐Label Study of Repeated Use of Diazepam Rectal Gel (Diastat) for Episodes of Acute Breakthrough Seizures and Clusters: Safety, Efficacy, and Tolerance
The objective is to assess safety of diazepam rectal gel for control of acute seizures in epilepsy patients and to evaluate tolerance with repeated use of DZPRG at intervals of ≤5 days. Expand
Bioavailability of Intranasal vs. Rectal Diazepam
- V. Ivaturi, R. Kriel, R. Brundage, G. Loewen, H. Mansbach, J. Cloyd
- Epilepsy Research
- 1 February 2013
It is concluded that intranasal DZP offers a viable alternative to rectal administration, but enhancement of formulations is needed to improve the extent and consistency of absorption. Expand