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Role of the synaptic ribbon in transmitting the cone light response
Cone photoreceptors distinguish small changes in light intensity while operating over a wide dynamic range. The cone synapse encodes intensity by modulating tonic neurotransmitter release, butExpand
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Streamlined Synaptic Vesicle Cycle in Cone Photoreceptor Terminals
Cone photoreceptors tonically release neurotransmitter in the dark through a continuous cycle of exocytosis and endocytosis. Here, using the synaptic vesicle marker FM1-43, we elucidate specializedExpand
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Light-activated ion channels for remote control of neuronal firing
Neurons have ion channels that are directly gated by voltage, ligands and temperature but not by light. Using structure-based design, we have developed a new chemical gate that confers lightExpand
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Spanning binding sites on allosteric proteins with polymer-linked ligand dimers
One approach to drug design involves determination of the structure of binding sites on target proteins to provide templates for ligand construction. Alternatively, random combinations of chemicalExpand
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Allosteric control of an ionotropic glutamate receptor with an optical switch
The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory binding site is a mechanism of regulation found across proteinExpand
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Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons
We have cloned a functional cDNA encoding the cyclic nucleotide-gated channel selectively expressed in catfish olfactory sensory neurons. The cyclic nucleotide-gated channels share sequence andExpand
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Remote Control of Neuronal Activity with a Light-Gated Glutamate Receptor
The ability to stimulate select neurons in isolated tissue and in living animals is important for investigating their role in circuits and behavior. We show that the engineered light-gated ionotropicExpand
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A Positive Feedback Synapse from Retinal Horizontal Cells to Cone Photoreceptors
Cone photoreceptors and horizontal cells (HCs) have a reciprocal synapse that underlies lateral inhibition and establishes the antagonistic center-surround organization of the visual system. ConesExpand
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Cyclic-nucleotide-gated channels mediate synaptic feedback by nitric oxide
Cyclic-nucleotide-gated (CNG) channels in outer segments of vertebrate photoreceptors generate electrical signals in response to changes in cyclic GMP concentration during phototransduction. CNGExpand
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Intracellular Ca2+ regulates the sensitivity of cyclic nucleotide-gated channels in olfactory receptor neurons
In olfactory receptor neurons, odorants stimulate production of cAMP, which directly activates cyclic nucleotide-gated (CNG) channels. Olfactory adaptation is thought to result from a rise inExpand
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