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MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised,
Objectives To determine the safety, tolerability and signs of efficacy of MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor (GM-CSF), in patients with rheumatoidExpand
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Increased susceptibility of gastric mucosa to ulcerogenic stimulation in diabetic rats–role of capsaicin‐sensitive sensory neurons
1 We examined the gastric mucosal blood flow (GMBF) and ulcerogenic responses following barrier disruption induced by sodium taurocholate (TC) in diabetic rats and investigated the role ofExpand
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Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis
Objectives: To determine the safety, pharmacokinetics (PK), and immunogenicity of the recombinant human monoclonal antibody MOR103 to granulocyte-macrophage colony-stimulating factor (GM-CSF) inExpand
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Role of nitric oxide in regulation of gastric acid secretion in rats: effects of NO donors and NO synthase inhibitor
1 The role of nitric oxide (NO) in the regulation of acid secretion was examined in the anaesthetized rat. 2 A rat stomach was mounted in an ex vivo chamber, instilled with 2 ml of saline every 15Expand
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Differential salutary effects of nonselective and selective COX-2 inhibitors in postoperative ileus in rats.
BACKGROUND Postoperative ileus (PI) is a common surgical complication, the treatment of which consists of supportive measures. AIM The effects of several cyclooxygenase (COX) inhibitors and theirExpand
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The role and interactions of nitric oxide (NO), carbon monoxide (CO), and prostanoids in the pathogenesis of postoperative ileus in rats
The effects of heme oxygenase (HO) inhibitors, zinc-protoporphyrin-IX (ZnPP-IX), and tin protoporphyrin-IX (SnPP-IX) and their interactions with L-arginine/nitric oxide synthase (NOS) andExpand
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Endothelin receptor blockers protect against ischemia/reperfusion impairment of gastrointestinal motility in rats.
Intestinal ischemia/reperfusion (I/R) injury remains associated with high morbidity and mortality. The protective efficacy of the following endothelin (ET) receptor blockers: BQ-123 (ET(A) receptor),Expand
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Polaprezinc Exerts a Salutary Effect on Impaired Healing of Acute Gastric Lesions in Diabetic Rats
We examined the influence of diabetes mellitus (DM) on the healing of HCl-induced gastric lesions and the healing promoting effect of polaprezinc [N-(3-aminopropionyl)-l-histidinato zinc] on theseExpand
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Role of nitric oxide in pathogenesis of serotonine-induced gastric lesions in rats.
We investigated the role of nitric oxide (NO) in the development of gastric mucosal lesions induced by serotonine (5-HT) in rats. Repeated subcutaneous administration of 5-HT (20 mg kg-1) producedExpand
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