R. Kornberg

Publications382
h-index112
Citations43,860
Highly Influential Citations1,902
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Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
TLDR
Structures of a 10-subunit yeast RNA polymerase II derived from two crystal forms at 2.8 and 3.1 angstrom resolution provide evidence for RNA exit in the vicinity of the carboxyl-terminal repeat domain, coupling synthesis to RNA processing by enzymes bound to this domain.
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
TLDR
The crystal structure of RNA polymerase II in the act of transcription was determined at 3.3 Å resolution and protein–nucleic acid contacts help explain DNA and RNA strand contacts, the specificity of RNA synthesis, “abortive cycling” during transcription initiation, and RNA and DNA translocation during transcription elongation.
Chromatin structure: a repeating unit of histones and DNA.
TLDR
Preliminary results do show less cross-linking of histones in chromatin than in solution, but crosslinked products up to pentamers are readily observed and call for further investigation.
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
RSC, an Essential, Abundant Chromatin-Remodeling Complex
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
Architecture of RNA polymerase II and implications for the transcription mechanism.
TLDR
A backbone model of a 10-subunit yeast RNA polymerase II has been derived from x-ray diffraction data extending to 3 angstroms resolution, and features of the model include a pair of jaws that appear to grip DNA downstream of the active center.
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
The structure of the general transcription factor IIB (TFIIB) in a complex with RNA polymerase II reveals three features crucial for transcription initiation: an N-terminal zinc ribbon domain of…
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