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Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification
Reactive oxygen species (ROS) and other radicals are involved in a variety of biological phenomena, such as mutation, carcinogenesis, degenerative and other diseases, inflammation, aging, andExpand
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Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.
Melatonin was found to be a potent free radical scavenger in 1993. Since then over 800 publications have directly or indirectly confirmed this observation. Melatonin scavenges a variety of reactiveExpand
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Skin antioxidants: their role in aging and in oxidative stress--new approaches for their evaluation.
  • R. Kohen
  • Medicine, Biology
  • Biomedicine & pharmacotherapy = Biomedecine…
  • 1 May 1999
Skin is a highly metabolic tissue which possesses the largest surface area in the body and serves as the protective layer for internal organs [1]. Skin is also a major candidate and target ofExpand
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Interplay among oxidants, antioxidants, and cytokines in skin disorders: present status and future considerations.
The pathogenicity of skin disorders involves a complexity of physiological, immunological, environmental, and genetic phenomena. This review focuses on cross-talks between two main agents, theExpand
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Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones.
Polyphenols, which occur both in edible plants and in foodstuff, have been reported to exert a wide range of health effects; however, the mechanism of action of these molecules is not fullyExpand
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N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant
The biogenic amine N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine (AFMK) was investigated for its potential antioxidative capacity. AFMK is a metabolite generated through either an enzymatic or a chemicalExpand
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Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization
A variety of mechanisms has been suggested for cocaine toxicity, including the possibility that cocaine induces an increase in oxidative stress (OS) due to excessive oxidation of dopamine (e.g.Expand
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A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products
Current evidence supports a contribution of polyphenols to the prevention of cardiovascular disease, but their mechanisms of action are not understood. We investigated the impact of red wineExpand
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Lipid peroxidation and coupled vitamin oxidation in simulated and human gastric fluid inhibited by dietary polyphenols: health implications.
The Western diet contains large quantities of oxidized lipids, because a large proportion of the food in the diet is consumed in a fried, heated, processed, or stored form. We investigated theExpand
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Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury.
Apolipoprotein E deficient mice have distinct memory deficits and neurochemical derangements and their recovery from closed head injury is impaired. In the present study, we examined the possibilityExpand
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