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Genome-wide analysis of mammalian promoter architecture and evolution
Mammalian promoters can be separated into two classes, conserved TATA box–enriched promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-rich promoters. We haveExpand
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The Transcriptional Landscape of the Mammalian Genome
This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. WeExpand
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GRC5 and NMD3 function in translational control of gene expression and interact genetically
Abstract The yeast gene, GRC5 (growth control), is a member of the highly conserved QM gene family, the human member of which has been associated with the suppression of Wilms' tumor. GRC5 encodesExpand
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Large number of ultraconserved elements were already present in the jawed vertebrate ancestor.
Stephen (2008) identified 13,736 ultraconserved elements (UCEs) in placental mammals and investigated their evolution in opossum, chicken, frog, and fugu. They found that there was a massiveExpand
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Cloning, expression and characterization of two new IgE-binding proteins from the yeast Malassezia sympodialis with sequence similarities to heat shock proteins and manganese superoxide dismutase.
Malassezia sympodialis is an opportunistic yeast that colonizes human skin and may induce IgE and T cell reactivity in patients with atopic eczema/dermatitis syndrome (AEDS). Previously, we haveExpand
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Extraction, amplification and detection of DNA in microfluidic chip-based assays
This review covers three aspects of PCR-based microfluidic chip assays: sample preparation, target amplification, and product detection. Expand
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Rapid identification of allergen-encoding cDNA clones by phage display and high-density arrays.
We describe a high-throughput, quantitative technology for fast identification of all different clones present in selectively enriched phage surface-displayed cDNA libraries. The strategy is based onExpand
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High Sensitivity TSS Prediction: Estimates of Locations Where TSS Cannot Occur
Background Although transcription in mammalian genomes can initiate from various genomic positions (e.g., 3′UTR, coding exons, etc.), most locations on genomes are not prone to transcriptionExpand
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Tapping Allergen Repertoires by Advanced Cloning Technologies
Background: Complex allergenic sources such as moulds, foods and mites contain complex panels of IgE-binding molecules which need to be cloned, produced and characterized in order to mimic the entireExpand
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