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Pharmacokinetics of the thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) in tumor-bearing rats.
Results indicate that FMAU may be useful for imaging tissue DNA synthesis, although tumor uptake was modest and not well correlated with growth rate among the models examined. Expand
Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations.
A reversed-phase HPLC method was developed and validated for the simultaneous determination of hypericins and stabilized hyperforin in St. John's wort extract and may be applied for the routine standardization of St. Johns wort products against hyper forin and thehypericins, the putative antidepressant principles in the herbal. Expand
Comparison of dissolution rates of different crystalline phases of fluprednisolone by in vitro and in vivo methods.
In vitro dissolution rates of six crystalline phases of fluprednisolone were determined and compared with in vivo dissolution rates from pellet implants in rats and correlations were obtained with animal weight loss and adrenal gland atrophy. Expand
Effect of Vehicles and Penetration Enhancers on the In Vitro and In Vivo Percutaneous Absorption of Methotrexate and Edatrexate Through Hairless Mouse Skin
Results of this study show the feasibility of using a transdermal delivery system of MTX and EDAM for the treatment of rheumatoid arthritis. Expand
Pharmacokinetics, pharmacology of atenolol and effect of renal disease.
The pharmacokinetics of intravenous and oral atenolol (50 mg) in six healthy volunteers was studied and reductions in resting heart rate and arterial blood pressure were proportional to either the logarithm of dose or area under the plasma concentration time curve or cumulative urinary atenolate excretion. Expand
Mitomycin-C concentration in human aqueous humour following trabeculectomy
MMC is detectable in aqueous humour within minutes of external application and the aQueous concentration level is higher if the application is in the scleral bed than on the episclera, and toxicity of the drug at this concentration range for corneal endothelial cells needs further investigation via in vitro and clinical studies. Expand
The ocular distribution of bunolol in the eyes of albino and pigmented rabbits.
The results of this study support the previously reported finding with timolol which showed longer retention of the drug in the iris, ciliary, choroid, and retina of pigmented rabbits than albinos. Expand
Determining hyperforin and hypericin content in eight brands of St. John's wort.
Fluorometric determination of methyldopa in biological fluids.
  • B. K. Kim, R. Koda
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1 November 1977
A fluorometric method for the analysis of methyldopa, based on the formation of a fluorophore after oxidation and rearrangement, is described, suitable for pharmacokinetic studies following therapeutic doses in animals and humans. Expand
Oculotoxicities of systemically administered drugs.
Various drug entry and exit pathways in the eye are presented and the role of some intraocular structures in the toxicity development is examined, including melanin binding, genetic heterogeneity, photosensitivity and environmental pollution. Expand