Share This Author
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
The application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells is reported and it is shown that chromatin state can be read in an allele-specific manner by using single nucleotide polymorphisms.
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
It is proposed that large CpG islands depleted of activating motifs confer epigenetic memory by recruiting the full repertoire of Polycomb complexes in pluripotent cells.
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells
A causal role for GC-rich sequences in PRC2 recruitment is demonstrated and a specific subset of CpG islands depleted of activating motifs are implicate as instrumental for the initial localization of this key regulator in mammalian genomes.
Reprogramming factor expression initiates widespread targeted chromatin remodeling.
Loss of BAP1 function leads to EZH2-dependent transformation
It is demonstrated that Bap1 loss in mice results in increased trimethylated histone H3 lysine 27 (H3K27me3), elevated enhancer of zeste 2 polycomb repressive complex 2 subunit (Ezh2) expression, and enhanced repression of polycomb repression complex 2 (PRC2) targets.
H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions
The authors' findings associate H2A.Z with functionally distinct genomic elements, and suggest that post-translational modifications may reconcile its contrasting locations and roles, which are associated with nucleosome exchange, transcriptional activation and Polycomb repression.
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
- O. Abdel-Wahab, Jie Gao, R. Levine
- Biology, MedicineThe Journal of experimental medicine
- 18 November 2013
Loss of Asxl1 results in myelodysplastic syndrome, whereas concomitant deletion of Tet2 restores HSC self-renewal and triggers a more severe disease phenotype distinct from that seen in single-gene…
The MicrobesOnline Web site for comparative genomics.
The Virtual Institute for Microbial Stress and Survival has developed a publicly available suite of Web-based comparative genomic tools designed to facilitate multispecies comparison among prokaryotes.
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
The combination of SIRT1 activators and DOT1L inhibitors shows enhanced antiproliferative activity against MLL-rearranged leukemia cells, indicating that the dynamic interplay between chromatin regulators controlling the activation and repression of gene expression could provide novel opportunities for combination therapy.