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Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone.
Four alkoxy analogues of naloxone and naltrexone were generated in contradiction to the predictions of the common anionic receptor site hypothesis and did not significantly alter oral/parenteral ratios of durations of action. Expand
New 14-aminomorphinones and codeinones.
N-Methylnalorphine: definition of N-allyl conformation for antagonism at the opiate receptor.
Drug Discovery by Combinatorial Chemistry—the Development of a Novel Method for the Rapid Synthesis of Single Compounds
Through the advantages conferred in the speed of synthesis, combinatorial chemistry is making a significant impact on the process of drug discovery. The mix-and-split paradigm has been an effectiveExpand
An investigation of the reaction of primary nitroalkanes with acetic anhydride/sodium acetate
Abstract Oxidation of primary nitroalkanes by acetic anhydride/sodium acetate has been found to be more complex than previously suspected. Phenylnitromethane, with acetic anhydride/sodium acetate atExpand
Chapter 4 Analgetics, Endorphins and the Opioid Receptor
Publisher Summary This chapter summarizes the significant advances in the knowledge of the biosynthesis and neurophysiology of endorphins, and the increased intensity of research stimulated by theExpand