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High Gamma Power Is Phase-Locked to Theta Oscillations in Human Neocortex
The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans. Expand
Voxel-based lesion–symptom mapping
VLSM maps for measures of speech fluency and language comprehension in 101 left-hemisphere-damaged aphasic patients confirm the anticipated contrast between anterior and posterior areas and indicate that interacting regions facilitate Fluency and auditory comprehension, in agreement with findings from modern brain imaging. Expand
Frontal Lobe Contributions to Theory of Mind
Patients with bilateral damage to orbito-frontal cortex and unilateral damage in left dorsolateral prefrontal cortex performed similarly to individuals with Asperger's syndrome, performing well on simpler tests and showing deficits on tasks requiring more subtle social reasoning, such as the ability to recognize a faux pas. Expand
The functional role of cross-frequency coupling
CFC might serve as a mechanism to transfer information from large-scale brain networks operating at behavioral timescales to the fast, local cortical processing required for effective computation and synaptic modification, thus integrating functional systems across multiple spatiotemporal scales. Expand
Decreased response to novel stimuli after prefrontal lesions in man.
  • R. Knight
  • Psychology, Medicine
  • Electroencephalography and clinical…
  • 1 February 1984
Findings indicate that prefrontal regions are critical for the organism's response to unexpected novel stimuli, and abnormalities in prefrontal control of sensory-limbic integration may be a critical element in the decreased P300 to novel stimuli found in these unilateral prefrontal lesioned patients. Expand
Prefrontal–cingulate interactions in action monitoring
The lateral prefrontal cortex seemed to interact with the anterior cingulate cortex in monitoring behavior and in guiding compensatory systems, and it was found that medial frontal cortex activity associated with action monitoring depended on activity in the lateral cortex. Expand
Contribution of human hippocampal region to novelty detection
  • R. Knight
  • Biology, Medicine
  • Nature
  • 19 September 1996
THE ability to respond to unexpected stimuli (the 'orienting response') is a fundamental characteristic of mammalian behaviour1, but the brain mechanisms by which novelty is detected remain poorlyExpand
Categorical Speech Representation in Human Superior Temporal Gyrus
This work found that listening to synthesized speech stimuli varying in small and acoustically equal steps evoked distinct and invariant cortical population response patterns that were organized by their sensitivities to critical acoustic features. Expand
Effects of extensive temporal lobe damage or mild hypoxia on recollection and familiarity
It is found that the regions disrupted in mild hypoxia, such as the hippocampus, are centrally involved in conscious recollection, whereas the surrounding temporal lobe supports familiarity-based memory discrimination. Expand
Age-related top-down suppression deficit in the early stages of cortical visual memory processing
Electroencephalography data reconcile two cognitive aging hypotheses by revealing that an interaction of deficits in inhibition and processing speed contributes to age-related cognitive impairment. Expand