Share This Author
Genomic DNA methylation: the mark and its mediators.
JmjC-domain-containing proteins and histone demethylation
The evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins is analysed and their cellular functions in relation to their potential enzymatic activities are discussed.
Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
The results indicate that candidate oncogenic pathways in IDH‐associated malignancy should include those that are regulated by other 2OG oxygenases than HIF hydroxylases, in particular those involving the regulation of histone methylation.
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
It is demonstrated that JHDM3A (jumonji C (JmjC)-domain-containing histone demethylase 3A) is capable of removing the me3 group from modified H3 lysine 9 (H3K9) and H3Lysine 36 (H2K36), indicating that J HDD3A may function in euchromatin to remove histone methylation marks that are associated with active transcription.
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
It is postulate that phosphorylation of MeCP2 modulates its dynamic function in neurons transiting between resting and active states within neural circuits that underlie behaviors.
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
It is discovered that KDM2B (FBXL10) specifically recognizes non-methylated DNA in CGIs and recruits the polycomb repressive complex 1 (PRC1), which contributes to histone H2A lysine 119 ubiquitylation (H2AK119ub1) and gene repression.
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.