Myocardial Infarct Size and Ventricular Function in Rats
- M. Pfeffer, J. Pfeffer, E. Braunwald
- Medicine, BiologyCirculation Research
- 1 April 1979
In this model of histologically healed myocardial infarction, the impairment of left ventricular function was directly related to the loss of myocardium, and the entire spectrum of postinfarction ventricularfunction was observed, from no detectable impairment to congestive failure.
The "no-reflow" phenomenon after temporary coronary occlusion in the dog.
- R. Kloner, C. Ganote, R. Jennings
- Medicine, BiologyJournal of Clinical Investigation
- 1 December 1974
Results suggest that 40 minutes of ischemia were tolerated by the capillary bed of the dog heart without serious capillary damage or perfusion defects, but that 90 min of ischemic injury was associated with the "no-reflow" phenomenon, i.e., failure to achieve uniform reperfusion.
Regional Ischemic 'Preconditioning' Protects Remote Virgin Myocardium From Subsequent Sustained Coronary Occlusion
- K. Przyklenk, B. Bauer, M. Ovize, R. Kloner, P. Whittaker
- Medicine, BiologyCirculation
- 1 March 1993
Brief episodes of ischemia in one vascular bed protect remote, virgin myocardium from subsequent sustained coronary artery occlusion in this canine model, and implies that preconditioning may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemic/reperfusion.
The Stunned Myocardium: Prolonged, Postischemic Ventricular Dysfunction
- E. Braunwald, R. Kloner
- Medicine, BiologyCirculation
- 1 December 1982
If prolonged, chronic postischemic left ventricular dysfunction can progress to myocardial scarring and ischemic cardiomyopathy, it may be important to determine how often it can be ameliorated by permanent improvement of myocardia perfusion by surgical treatment.
Systemic Delivery of Bone Marrow–Derived Mesenchymal Stem Cells to the Infarcted Myocardium: Feasibility, Cell Migration, and Body Distribution
- I. Barbash, P. Chouraqui, J. Leor
- Biology, MedicineCirculation
- 19 August 2003
Systemic intravenous delivery of BM-MSCs to rats after MI, although feasible, is limited by entrapment of the donor cells in the lungs, which enhances migration and colonization of the cells preferentially to the ischemic myocardium.
Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
- R. Gottlieb, K. Burleson, R. Kloner, B. Babior, R. Engler
- Biology, MedicineJournal of Clinical Investigation
- 1 October 1994
Parts of apoptosis (programmed cell death) in myocytes are identified as a response to reperfusion but not ischemia, which indicates that apoptosis may be a specific feature of reperfusions injury in cardiac myocytes, leading to late cell death.
Allogeneic Mesenchymal Stem Cell Transplantation in Postinfarcted Rat Myocardium: Short- and Long-Term Effects
Allogeneic MSCs survive in infarcted myocardium as long as 6 months and express markers that suggest muscle and endothelium phenotypes, which suggests a possible early paracrine effect.
A systematic review of the association between erectile dysfunction and cardiovascular disease.
- G. Gandaglia, A. Briganti, C. Vlachopoulos
- Medicine, BiologyEuropean Urology
- 1 May 2014
The effects of acute and chronic cocaine use on the heart.
- R. Kloner, S. Hale, K. Alker, S. Rezkalla
- Medicine, BiologyCirculation
- 1 February 1992
Young patients who present with acute myocardial infarction, especially without other risk factors, should be questioned regarding use of cocaine, and the correct therapy for cocaine cardiotoxicity is not known.
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