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Myocardial Infarct Size and Ventricular Function in Rats
TLDR
In this model of histologically healed myocardial infarction, the impairment of left ventricular function was directly related to the loss of myocardium, and the entire spectrum of postinfarction ventricularfunction was observed, from no detectable impairment to congestive failure.
Regional Ischemic 'Preconditioning' Protects Remote Virgin Myocardium From Subsequent Sustained Coronary Occlusion
TLDR
Brief episodes of ischemia in one vascular bed protect remote, virgin myocardium from subsequent sustained coronary artery occlusion in this canine model, and implies that preconditioning may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemic/reperfusion.
The "no-reflow" phenomenon after temporary coronary occlusion in the dog.
TLDR
Results suggest that 40 minutes of ischemia were tolerated by the capillary bed of the dog heart without serious capillary damage or perfusion defects, but that 90 min of ischemic injury was associated with the "no-reflow" phenomenon, i.e., failure to achieve uniform reperfusion.
The Stunned Myocardium: Prolonged, Postischemic Ventricular Dysfunction
TLDR
If prolonged, chronic postischemic left ventricular dysfunction can progress to myocardial scarring and ischemic cardiomyopathy, it may be important to determine how often it can be ameliorated by permanent improvement of myocardia perfusion by surgical treatment.
Systemic Delivery of Bone Marrow–Derived Mesenchymal Stem Cells to the Infarcted Myocardium: Feasibility, Cell Migration, and Body Distribution
TLDR
Systemic intravenous delivery of BM-MSCs to rats after MI, although feasible, is limited by entrapment of the donor cells in the lungs, which enhances migration and colonization of the cells preferentially to the ischemic myocardium.
Allogeneic Mesenchymal Stem Cell Transplantation in Postinfarcted Rat Myocardium: Short- and Long-Term Effects
TLDR
Allogeneic MSCs survive in infarcted myocardium as long as 6 months and express markers that suggest muscle and endothelium phenotypes, which suggests a possible early paracrine effect.
Management of sexual dysfunction in patients with cardiovascular disease: recommendations of the Princeton Consensus Panel.
TLDR
A simple algorithm is provided for guiding physicians in the management of sexual dysfunction in patients with varying degrees of cardiac risk, including patients with a history of uncomplicated myocardial infarction.
Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
TLDR
Parts of apoptosis (programmed cell death) in myocytes are identified as a response to reperfusion but not ischemia, which indicates that apoptosis may be a specific feature of reperfusions injury in cardiac myocytes, leading to late cell death.
The effects of acute and chronic cocaine use on the heart.
TLDR
Young patients who present with acute myocardial infarction, especially without other risk factors, should be questioned regarding use of cocaine, and the correct therapy for cocaine cardiotoxicity is not known.
The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease.
TLDR
The Panel's recommendations build on those developed during the first and second Princeton Consensus Conferences, first emphasizing the use of exercise ability and stress testing to ensure that each man's cardiovascular health is consistent with the physical demands of sexual activity before prescribing treatment for ED, and second highlighting the link between ED and CVD, which may be asymptomatic and may benefit from cardiovascular risk reduction.
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