• Publications
  • Influence
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
Pentameric ligand gated ion-channels, or Cys-loop receptors, mediate rapid chemical transmission of signals. This superfamily of allosteric transmembrane proteins includes the nicotinic acetylcholineExpand
  • 1,623
  • 158
  • PDF
Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity
Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a stable andExpand
  • 46
  • 6
Crystal Structure of Acetylcholine-binding Protein from Bulinus truncatus Reveals the Conserved Structural Scaffold and Sites of Variation in Nicotinic Acetylcholine Receptors*
The crystal structure of acetylcholine-binding protein (AChBP) from the mollusk Lymnaea stagnalis is the established model for the ligand binding domains of the ligand-gated ion channel family, whichExpand
  • 178
  • 4
The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory
Glutamatergic synapses rely on AMPA receptors (AMPARs) for fast synaptic transmission and plasticity. AMPAR auxiliary proteins regulate receptor trafficking, and modulate receptor mobility and itsExpand
  • 33
  • 2
Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.
Autism is a human developmental brain disorder characterized by impaired social interaction and communication. Contactin-associated protein-like 2 (Caspr2, CNTNAP2) is a known genetic risk factor ofExpand
  • 30
  • 2
  • PDF
Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex
The group 1 metabotropic glutamate receptors 1 and 5 (mGluR1/5) have been implicated in mechanisms of synaptic plasticity and may serve as potential therapeutic targets in autism spectrum disorders.Expand
  • 29
  • PDF
C-Terminal Interactors of the AMPA Receptor Auxiliary Subunit Shisa9
Shisa9 (initially named CKAMP44) has been identified as auxiliary subunit of the AMPA-type glutamate receptors and was shown to modulate its physiological properties. Shisa9 is a type-I transmembraneExpand
  • 18
  • PDF
AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation
Summary The majority of excitatory postsynaptic currents in the brain are gated through AMPA-type glutamate receptors, the kinetics and trafficking of which can be modulated by auxiliary proteins. ItExpand
  • 4
  • PDF