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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.
TLDR
It is suggested that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice.
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets.
TLDR
The results suggest that FSP27 contributes to efficient energy storage in WAT by promoting the formation of unilocular lipid droplets, thereby restricting lipolysis and finding that the nature of lipid accumulation in Wat appears to be associated with maintenance of energy balance and insulin sensitivity.
Chemerin regulates β-cell function in mice
TLDR
It is shown that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue, indicating thatChemerin regulates β-cell function and plays an important role in glucose homeostasis in a tissue-dependent manner.
Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.
TLDR
It is suggested that IL-6 is not essential for increasing bone resorption in the early postovariectomy period, and IL-1 and TNF play a direct role in mediating the effects of ovx on osteoclastogenesis and bone Resorption.
Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients.
TLDR
The results suggest that the depressed expression of the Klotho-FGFR1 complex in hyperplastic glands underlies the pathogenesis of SHPT and its resistance to extremely high FGF23 levels in uremic patients.
Vitamin D3 supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter
TLDR
Results provide direct evidence that 1α,25 dihydroxyvitamin D3 augments osteoclastogenesis by transactivating the human RANKL gene in osteoblastic cells through VDRE.
Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency.
TLDR
It is suggested that GH plays an essential role in the metabolic and redox regulation in the liver and the abnormal lipid profile concomitant with a marked reduction in oxidative stress.
Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy.
TLDR
The effect of GH replacement therapy suggests that the NAFLD is predominantly attributable to GHD, and adult hypopituitary patients with GHD demonstrated a highNAFLD prevalence.
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