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  • Influence
The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system
TLDR
It is shown that regulatory components of the venom secretory system may have evolved from a pancreatic origin and that venom toxin genes were co-opted by distinct genomic mechanisms, which provides insight into mechanisms of protein evolution under strong selection. Expand
Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes.
  • R. Kini
  • Biology, Medicine
  • Toxicon : official journal of the International…
  • 1 December 2003
TLDR
Identification of the pharmacological sites has potential for exploitation in development of novel systems useful for 'delivering' specific proteins to a particular target tissue or organ and research in this field will provide a lot of exciting opportunities. Expand
Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms.
  • R. Kini
  • Biology, Medicine
  • Toxicon : official journal of the International…
  • 15 June 2005
TLDR
These studies strongly support the target model which suggests that protein-protein interaction rather than protein-phospholipid interaction determines the pharmacological specificity of PLA(2) enzymes. Expand
Anticoagulant proteins from snake venoms: structure, function and mechanism.
  • R. Kini
  • Biology, Medicine
  • The Biochemical journal
  • 1 August 2006
TLDR
The details of the structure, mechanism and structure-function relationships of anticoagulant proteins from snake venoms are described. Expand
Venom phospholipase A[2] enzymes : structure, function, and mechanism
TLDR
Partial table of contents: Molecular Biology of Snake Venom Phospholipases A2 (J. Danse, et al.) and Molecular Events in the Myotoxic Action of Ph phospholipase A2. Expand
Protein complexes in snake venom
  • R. Doley, R. Kini
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • 4 June 2009
TLDR
The structure and function of various protein complexes of snake venoms and their role in snake venom toxicity are described. Expand
Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: evolutionary and toxinological implications.
TLDR
The large body of data on molecular masses and retention times thus assembled demonstrates a hitherto unsuspected diversity of toxins in all lineages, having implications ranging from clinical management of envenomings to venom evolution to the use of isolated toxins as leads for drug design and development. Expand
Structure, function and evolution of three-finger toxins: mini proteins with multiple targets.
  • R. Kini, R. Doley
  • Biology, Medicine
  • Toxicon : official journal of the International…
  • 1 November 2010
TLDR
This review describes the structural and functional diversity, structure-function relationships and evolution of three-finger toxins, a group of snake venom toxins found in all families of snakes. Expand
Molecular Evolution and Phylogeny of Elapid Snake Venom Three-Finger Toxins
TLDR
The purpose of this study was to investigate the long-term evolutionary patterns exhibited by these snake venom toxins to understand the mechanisms by which they diversified into a large, biochemically diverse, multigene family. Expand
Serine Proteases Affecting Blood Coagulation and Fibrinolysis from Snake Venoms
  • R. Kini
  • Chemistry, Medicine
  • Pathophysiology of Haemostasis and Thrombosis
  • 1 May 2006
TLDR
These serine proteases serve as tools to study molecular details in the activation of specific factors involved in coagulation and fibrinolytic cascades and are useful in treating various thrombotic and hemostatic conditions. Expand
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