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GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.
TLDR
It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks. Expand
Early motor activity drives spindle bursts in the developing somatosensory cortex
TLDR
It is suggested that the interaction between movement-triggered sensory feedback signals and self-organized spindle oscillations shapes the formation of cortical connections required for sensorimotor coordination. Expand
Retinal Waves Trigger Spindle Bursts in the Neonatal Rat Visual Cortex
TLDR
Using simultaneous recordings from the rat retina and visual cortex during the first postnatal week in vivo, it is found that spontaneous retinal bursts are correlated with spindle bursts (intermittent network bursts associated withSpindle-shape field oscillations) in the contralateral visual cortex (V1). Expand
Correlated Bursts of Activity in the Neonatal Hippocampus in Vivo
TLDR
Recurrent bursts of synchronized neuronal activity lasting 0.5 to 3 seconds that occurred spontaneously in the hippocampus of freely moving and anesthetized rat pups may underlie activity-dependent maturation of the hippocampal network. Expand
Early patterns of electrical activity in the developing cerebral cortex of humans and rodents
TLDR
There is considerable evidence that the basic functional properties of immature cortical networks are conserved through mammalian evolution, making the neonatal rodent an excellent model for studying early cortical activity and associated plasticity during the developmental period corresponding to the human fetal stage. Expand
Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery
TLDR
It is found that, shortly before delivery, there is a transient reduction in the intracellular chloride concentration and an excitatory-to-inhibitory switch of GABA actions, which are triggered by oxytocin, an essential maternal hormone for labor. Expand
A Conserved Switch in Sensory Processing Prepares Developing Neocortex for Vision
TLDR
A "bursting" period of visual responsiveness during which the weak retinal output is amplified by endogenous network oscillations, enabling a primitive form of vision and ending shortly before delivery in humans and eye opening in rodents. Expand
Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo.
TLDR
It is proposed that local spindle-burst oscillations, driven by glutamatergic synapses and spatially confined by GABAergic synapses, contribute to the development of barrel cortex during the critical period of developmental plasticity. Expand
Excitatory GABA in rodent developing neocortex in vitro.
TLDR
A strong GABA excitatory drive coupled with high intrinsic excitability of L5/6 pyramidal neurons and interneurons provide a powerful mechanism of synapse-driven oscillatory activity in the rodent neocortex in vitro. Expand
Rapid cortical oscillations and early motor activity in premature human neonate.
TLDR
It is proposed that in the human fetus in utero, before the brain starts to receive elaborated sensory input from the external world, spontaneous fetal movements provide sensory stimulation and drive delta-brush oscillations in the developing somatosensory cortex contributing to the formation of cortical body maps. Expand
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