• Publications
  • Influence
Heterogenous Nature of Flow-Mediated Dilatation in Human Conduit Arteries In Vivo: Relevance to Endothelial Dysfunction in Hypercholesterolemia
Abstract — Flow-mediated dilatation (FMD) of conduit arteries is dependent on an intact endothelium, although the mechanisms are not fully understood. Using high-resolution ultrasound, we examinedExpand
  • 399
  • 49
  • PDF
Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial
BACKGROUND Remote ischaemic preconditioning attenuates cardiac injury at elective surgery and angioplasty. We tested the hypothesis that remote ischaemic conditioning during evolving ST-elevationExpand
  • 851
  • 42
  • PDF
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo.
BACKGROUND Endothelial dysfunction leading to neutrophil infiltration of tissues has been implicated in tissue injury caused by ischemia-reperfusion (IR). Tissue injury during IR can be reduced byExpand
  • 307
  • 23
  • PDF
Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans.
OBJECTIVES We conducted a randomized controlled trial of the effects of remote ischemic preconditioning (RIPC) in children undergoing repair of congenital heart defects. BACKGROUND Remote ischemicExpand
  • 523
  • 21
Mortality from infective endocarditis: clinical predictors of outcome
Objective: To identify clinical markers available within the first 48 hours of admission that are associated with poor outcome in infective endocarditis. Designs: Retrospective cohort study. Setting:Expand
  • 267
  • 18
  • PDF
Acute Systemic Inflammation Impairs Endothelium-Dependent Dilatation in Humans
BackgroundWe tested the hypothesis that endothelial dysfunction underlies the association between an acute inflammatory episode and the transiently increased risk of a cardiovascular event byExpand
  • 577
  • 17
Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction
BackgroundCurrent cardiovascular magnetic resonance (CMR) methods, such as late gadolinium enhancement (LGE) and oedema imaging (T2W) used to depict myocardial ischemia, have limitations. NovelExpand
  • 215
  • 16
The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans.
Remote ischemic preconditioning (IPC) reduces tissue injury caused by ischemia-reperfusion (IR) in distant organs. We tested the hypothesis that remote IPC (rIPC) modifies inflammatory geneExpand
  • 294
  • 13
  • PDF
Transient Limb Ischemia Induces Remote Ischemic Preconditioning In Vivo
Background—Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR injury of tissues remote from thoseExpand
  • 423
  • 12
Use of the Instantaneous Wave‐free Ratio or Fractional Flow Reserve in PCI
Background Coronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than revascularization guided by angiography alone. It isExpand
  • 400
  • 11
  • PDF