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Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum
TLDR
Results support traditional claims for A. muricata and A. reticulata in the treatment of malaria given their limited cytotoxicity profile, and qualify as promising starting points for antimalarial drug discovery. Expand
Potent antiplasmodial extracts and fractions from Terminalia mantaly and Terminalia superba
TLDR
The results achieved in this work validate the reported traditional use of Terminalia mantaly and Terminalia superba to treat malaria and warrant further investigation to characterize the active antiplasmodial principles and progress them to rodent malaria models studies if activity and selectivity are evidenced. Expand
Ethnobotanical survey of medicinal plants used as insects repellents in six malaria endemic localities of Cameroon
TLDR
This study has shown that rural populations of the 6 targeted localities possess indigenous knowledge on repellent plants that are otherwise cost-effective and better choice for repelling insects including malaria-transmitting mosquitoes. Expand
Antimycobacterial activity of medicinal plants against the causative agent of buruli ulcer: Mycobacterium ulcerans
TLDR
Assessment of the antimycobacterial properties of four medicinal plants against M. ulcerans strengthened the exploitation of these extracts as potent hits in the treatment of Buruli ulcer. Expand
In Vivo Antiplasmodial Activity of Terminalia mantaly Stem Bark Aqueous Extract in Mice Infected by Plasmodium berghei
TLDR
The results suggest that the stem bark extract of T. mantaly possesses antimalarial activity and was further assessed for acute toxicity and efficacy in Plasmodium berghei-infected mice. Expand
Identification of 3,3′-O-dimethylellagic acid and apigenin as the main antiplasmodial constituents of Endodesmia calophylloides Benth and Hymenostegia afzelii (Oliver.) Harms
TLDR
Two potent antiplasmodial natural compounds, 3,3′- O -dimethylellagic acid and apigenin that could serve as starting points for further antimalarial drug discovery are identified. Expand
Antifungal potential of extracts, fractions and compounds from Uvaria comperei (Annonaceae) and Oxyanthus unilocularis (Rubiaceae).
TLDR
Phytochemical study of Uvaria comperei afforded an alkaloid, 8,9-dimethoxy-5H-phenanthridin-6-one, isolated and characterised for the first time from a natural source along with two flavonoids that exhibited good antifungal activity against clinical isolates and standard strains of yeast species of Candida and Cryptococcus genera. Expand
Spirofused tetrahydroisoquinoline-oxindole hybrids as a novel class of fast acting antimalarial agents with multiple modes of action
TLDR
The data confirm the antiplasmodial activity of (±)-moxiquindole, and identify 3′4′-dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones as a novel class of antimalarial agents with multiple modes of action. Expand
Common bean (Phaseolus vulgaris L.) root rot in humid lowland: Occurrence, and assessment of biotic and agronomic factors for mitigation prospects
TLDR
This study provides clear evidence of high prevalence of BRR disease in the humid lowlands of Cameroon, and suggests deep ploughing and phosphoric fertilizer amendment with basic soil for managing BRR in lowland agro-ecosystems. Expand
In vitro anti-yeast activity, kinetics and mechanism of action of essential oils from two Cameroonian medicinal plants.
Background: Treatment of Candida infections, increasingly difficult due to antifungal drug resistance has drawn attention toward the search for innovative and effective drugs. Results: EssentialExpand