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Mesolimbic Dopamine Signals the Value of Work
The results indicate that dopamine conveys a single, rapidly evolving decision variable, the available reward for investment of effort, which is employed for both learning and motivational functions. Expand
Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells.
These measurements represent time-resolved observation of quantal secretion of catecholamine and provide direct evidence for the exocytotic hypothesis. Expand
Capillary electrophoresis.
Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.
Together, these data provide direct genetic evidence for a critical role for leptin signaling in islet biology and suggest that altered leptin action in islets is one factor that contributes to obesity-associated diabetes. Expand
Detection and imaging of zinc secretion from pancreatic beta-cells using a new fluorescent zinc indicator.
Heterogeneity in secretion among cells was indicated in that some cells in a cluster did not release Zn2+. Expand
Reducing time and increasing sensitivity in sample preparation for adherent mammalian cell metabolomics.
It is demonstrated that a rapid water rinse step prior to quenching of metabolism reduces components that suppress electrospray ionization thereby increasing signal for 26 of 27 targeted metabolites and increasing total number of detected features from 237 to 452 with no detectable change of metabolite content. Expand
Dynamic Observation of Dopamine Autoreceptor Effects in Rat Striatal Slices
Fast‐scan cyclic voltammetry has been used to measure dopamine (DA) synaptic overflow in slices of rat caudate nucleus induced by electrical stimulation with one‐, two‐, and 50‐pulse, 10‐Hz trains, suggesting that autoreceptors are not normally occupied in this preparation. Expand
Correlated Oscillations in Glucose Consumption, Oxygen Consumption, and Intracellular Free Ca2+ in Single Islets of Langerhans*
Monitoring of glucose and oxygen levels in the extracellular space of single islets of Langerhans in real-time suggested that during oscillations, bursts of glycolysis begin after Ca2+ has stopped entering the cell, which stimulates increases in respiration. Expand
Effects of Intrathecally Administered Nociceptin/Orphanin FQ in Monkeys: Behavioral and Mass Spectrometric Studies
The results provide the first functional evidence of spinal N/OFQ-induced antinociception in primates and indicate that activation of spinalNOP receptors may be a potential target for spinal analgesics. Expand
Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+ Stores in Insulin-stimulated Insulin Secretion in β-Cells*
The data suggest that autocrine-activated increases in [Ca2+] i are due to release of intracellular Ca2+ stores, especially the endoplasmic reticulum, mediated by insulin receptor substrate-1 and phosphatidylinositol 3-kinase. Expand