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Engineering the third wave of biocatalysis
- U. Bornscheuer, G. Huisman, R. Kazlauskas, S. Lutz, Jeffrey C. Moore, K. Robins
- Biology, EngineeringNature
- 10 May 2012
Applications of protein-engineered biocatalysts ranging from commodity chemicals to advanced pharmaceutical intermediates that use enzyme catalysis as a key step are discussed.
Hydrolases in Organic Synthesis: Regio- and Stereoselective Biotransformations
Using Enantioselective Reactions to Design and Optimize Biocatalyst Performance and Survey of EnantiOSElective Protease-and Amidase-Catalyzed Reactions.
Improving enzyme properties: when are closer mutations better?
How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.
Detailed analysis of the subset of α/β-hydrolase fold enzymes that contain the serine-histidine-aspartate catalytic triad shows that binding differences and non-catalytic residues create new mechanisms and are essential for understanding and designing efficient enzymes.
Biocatalysis in ionic liquids - advantages beyond green technology.
Improved preparation and use of room-temperature ionic liquids in lipase-catalyzed enantio- and regioselective acylations.
Ionic liquids permit reactions in a more polar solvent than previously possible, and lipase-catalyzed reactions that previously did not occur in untreated ionic liquids now occur at rates comparable to those in nonpolar organic solvents such as toluene.
Hydrolase-catalyzed biotransformations in deep eutectic solvents.
Hydrolases show good catalytic activity in deep eutectic solvents, despite the presence of urea, which can denature enzymes, or alcohols, which can interfere with hydrolase-catalyzed reactions.
A rule to predict which enantiomer of a secondary alcohol reacts faster in reactions catalyzed by cholesterol esterase, lipase from Pseudomonas cepacia, and lipase from Candida rugosa
Toward advanced ionic liquids. Polar, enzyme-friendly solvents for biocatalysis
- J. T. Gorke, F. Srienc, R. Kazlauskas
- ChemistryBiotechnology and bioprocess engineering : BBE
- 1 February 2010
This review covers selected examples of enzyme catalyzed reaction in ionic liquids that demonstrate their advantages and unique properties, and point out opportunities for new applications.