Share This Author
The genome of the social amoeba Dictyostelium discoideum
A proteome-based phylogeny shows that the amoebozoa diverged from the animal–fungal lineage after the plant–animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.
Chemotaxis in the Absence of PIP3 Gradients
Glycogen synthase kinase 3 regulates cell fate in dictyostelium
Ca2+ signalling is not required for chemotaxis in Dictyostelium
It is concluded that Ca2+ signalling is not necessary for chemotaxis to cAMP, and mutant cells chemotax efficiently towards cAMP or folic acid and their sensitivity tocAMP is similar to wild type.
Mechanism of eIF6 release from the nascent 60S ribosomal subunit
Cryo-EM structures of human SBDS and SBDS–EFL1 bound to Dictyostelium discoideum 60S ribosomal subunits with and without endogenous eIF 6 reveal the conserved mechanism of eIF6 release, which is corrupted in both inherited and sporadic leukemias.
The role of DIF-1 signaling in Dictyostelium development.
An intersection of the cAMP/PKA and two‐component signal transduction systems in Dictyostelium
- P. Thomason, D. Traynor, G. Cavet, Wen-Tsan Chang, A. Harwood, R. Kay
- BiologyThe EMBO journal
- 15 May 1998
It is proposed that cAMP breakdown is controlled by a phosphorelay system which activates RegA, and may include RdeA, which should be triggered when this system is inhibited.
Cyclic AMP is an inhibitor of stalk cell differentiation in Dictyostelium discoideum.
Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum.
Evidence is reported suggesting that cell differentiation can be brought about in normal development by the combinatorial action of two diffusible signals, cAMP and DIF-1.
Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion
It is shown that carbamazepine induces antimicrobial autophagy through a novel, evolutionarily conserved, mTOR‐independent pathway controlled by cellular depletion of myo‐inositol, and in mice infected with a highly virulent multidrug‐resistant MTB strain, carbazepine treatment reduced bacterial burden, improved lung pathology and stimulated adaptive immunity.