• Publications
  • Influence
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate.
Robert Kavlock a, Kim Boekelheide b, Robert Chapin c, Michael Cunningham c, Elaine Faustman d, Paul Foster e, Mari Golub f, Rogene Henderson g, Irwin Hinberg h, Ruth Little c, Jennifer Seed i,Expand
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The ToxCast program for prioritizing toxicity testing of environmental chemicals.
The U.S. Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS), and various toxicogenomic technologies to predictExpand
  • 634
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In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
Background Chemical toxicity testing is being transformed by advances in biology and computer modeling, concerns over animal use, and the thousands of environmental chemicals lacking toxicity data.Expand
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Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.
The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects includeExpand
  • 1,033
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Improving the Human Hazard Characterization of Chemicals: A Tox21 Update
Background: In 2008, the National Institute of Environmental Health Sciences/National Toxicology Program, the U.S. Environmental Protection Agency’s National Center for Computational Toxicology, andExpand
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Informing Selection of Nanomaterial Concentrations for ToxCast in Vitro Testing Based on Occupational Exposure Potential
Background: Little justification is generally provided for selection of in vitro assay testing concentrations for engineered nanomaterials (ENMs). Selection of concentration levels for hazardExpand
  • 126
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Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis
Background: A recent review by the International Agency for Research on Cancer (IARC) updated the assessments of the > 100 agents classified as Group 1, carcinogenic to humans (IARC Monographs VolumeExpand
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The Toxicity Data Landscape for Environmental Chemicals
Objective Thousands of chemicals are in common use, but only a portion of them have undergone significant toxicologic evaluation, leading to the need to prioritize the remainder for targeted testing.Expand
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Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data
Background The prioritization of chemicals for toxicity testing is a primary goal of the U.S. Environmental Protection Agency (EPA) ToxCast™ program. Phase I of ToxCast used a battery of 467 inExpand
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